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题名: Application of probabilistic neural network in the clinical diagnosis of cancers based on clinical chemistry data
作者: Shan, YC;  Zhao, RH;  Xu, GW;  Liebich, HM;  Zhang, YK
关键词: classification ;  cancer ;  nucleosides ;  probabilistic neural network
刊名: ANALYTICA CHIMICA ACTA
发表日期: 2002-10-23
卷: 471, 期:1, 页:77-86
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: As a recently developed and powerful classification tool, probabilistic neural network was used to distinguish cancer patients from healthy persons according to the levels of nucleosides in human urine. Two datasets (containing 32 and 50 patterns, respectively) were investigated and the total consistency rate obtained was 100% for dataset 1 and 94% for dataset 2. To evaluate the performance of probabilistic neural network, linear discriminant analysis and learning vector quantization network, were also applied to the classification problem. The results showed that the predictive ability of the probabilistic neural network is stronger than the others in this study. Moreover, the recognition rate for dataset 2 can achieve to 100% if combining, these three methods together, which indicated the promising potential of clinical diagnosis by combining different methods. (C) 2002 Elsevier Science B.V. All rights reserved.
关键词[WOS]: MASS-SPECTROMETRY ;  MODIFIED NUCLEOSIDES ;  PATTERN-RECOGNITION ;  RETENTION BEHAVIOR ;  SENSOR ARRAY ;  IDENTIFICATION ;  CLASSIFICATION ;  CHROMATOGRAPHY ;  CLASSIFIERS ;  TOOL
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000178565700008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/83249
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Acad Sinica, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Univ Tubingen, Med Klin, D-72076 Tubingen, Germany

Recommended Citation:
Shan, YC,Zhao, RH,Xu, GW,et al. Application of probabilistic neural network in the clinical diagnosis of cancers based on clinical chemistry data[J]. ANALYTICA CHIMICA ACTA,2002,471(1):77-86.
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