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Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation; Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation
Liu, XD; Bao, DC; Xue, WM; Xiong, Y; Yu, WT; Yu, XJ; Ma, XJ; Yuan, Q
关键词Polyelectrolytes Polyelectrolytes Gels Gels Drug Delivery Systems Drug Delivery Systems Membranes Membranes Gelation Gelation
刊名JOURNAL OF APPLIED POLYMER SCIENCE ; JOURNAL OF APPLIED POLYMER SCIENCE
2003-01-31 ; 2003-01-31
DOI10.1002/app.11537 ; 10.1002/app.11537
87期:5页:848-852
收录类别SCI ; SCI
文章类型Article ; Article
部门归属1802 ; 1802
项目归属1802 ; 1802
产权排名1;1 ; 1;1
WOS标题词Science & Technology ; Science & Technology ; Physical Sciences ; Physical Sciences
类目[WOS]Polymer Science ; Polymer Science
研究领域[WOS]Polymer Science ; Polymer Science
关键词[WOS]ALBUMIN MICROSPHERES ; ALBUMIN MICROSPHERES ; PARTICLE-SIZE ; PARTICLE-SIZE ; DELIVERY ; DELIVERY ; MICROPARTICLES ; MICROPARTICLES
英文摘要With the objective of making calcium alginate gel beads with small and uniform size, membrane emulsification coupled with internal gelation was proposed. Spherical gel beads with mean size of about 50 mum, and even smaller ones in water, and with narrow size distribution were successfully obtained. Experimental studies focusing mainly on the effect of process parameters on bead properties were performed. The size of the beads was mainly dependent on the diameter of the membrane pores. High transmembrane pressure made for large gel beads with wide size distribution. Low sodium alginate concentration produced nonspherical beads, whereas a high concentration was unsuitable for the production of small beads with narrow distribution. Thus 1.5% w/v was enough. A high surfactant concentration favored the formation of small beads, but the adverse effect on mass transfer should be considered in this novel process. (C) 2002 Wiley Periodicals, Inc.; With the objective of making calcium alginate gel beads with small and uniform size, membrane emulsification coupled with internal gelation was proposed. Spherical gel beads with mean size of about 50 mum, and even smaller ones in water, and with narrow size distribution were successfully obtained. Experimental studies focusing mainly on the effect of process parameters on bead properties were performed. The size of the beads was mainly dependent on the diameter of the membrane pores. High transmembrane pressure made for large gel beads with wide size distribution. Low sodium alginate concentration produced nonspherical beads, whereas a high concentration was unsuitable for the production of small beads with narrow distribution. Thus 1.5% w/v was enough. A high surfactant concentration favored the formation of small beads, but the adverse effect on mass transfer should be considered in this novel process. (C) 2002 Wiley Periodicals, Inc.
语种英语 ; 英语
原文出处查看原文 ; 查看原文
WOS记录号WOS:000179735700016 ; WOS:000179735700016
引用统计
被引频次:72[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/83375
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Liu, XD,Bao, DC,Xue, WM,et al. Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation, Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation[J]. JOURNAL OF APPLIED POLYMER SCIENCE, JOURNAL OF APPLIED POLYMER SCIENCE,2003, 2003,87, 87(5):848-852, 848-852.
APA Liu, XD.,Bao, DC.,Xue, WM.,Xiong, Y.,Yu, WT.,...&Yuan, Q.(2003).Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation.JOURNAL OF APPLIED POLYMER SCIENCE,87(5),848-852.
MLA Liu, XD,et al."Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation".JOURNAL OF APPLIED POLYMER SCIENCE 87.5(2003):848-852.
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