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Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation; Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation
Liu, XD; Bao, DC; Xue, WM; Xiong, Y; Yu, WT; Yu, XJ; Ma, XJ; Yuan, Q
KeywordPolyelectrolytes Polyelectrolytes Gels Gels Drug Delivery Systems Drug Delivery Systems Membranes Membranes Gelation Gelation
Source PublicationJOURNAL OF APPLIED POLYMER SCIENCE ; JOURNAL OF APPLIED POLYMER SCIENCE
2003-01-31 ; 2003-01-31
DOI10.1002/app.11537 ; 10.1002/app.11537
Volume87Issue:5Pages:848-852
Indexed BySCI ; SCI
SubtypeArticle ; Article
Department1802 ; 1802
Funding Project1802 ; 1802
Contribution Rank1;1 ; 1;1
WOS HeadingsScience & Technology ; Science & Technology ; Physical Sciences ; Physical Sciences
WOS SubjectPolymer Science ; Polymer Science
WOS Research AreaPolymer Science ; Polymer Science
WOS KeywordALBUMIN MICROSPHERES ; ALBUMIN MICROSPHERES ; PARTICLE-SIZE ; PARTICLE-SIZE ; DELIVERY ; DELIVERY ; MICROPARTICLES ; MICROPARTICLES
AbstractWith the objective of making calcium alginate gel beads with small and uniform size, membrane emulsification coupled with internal gelation was proposed. Spherical gel beads with mean size of about 50 mum, and even smaller ones in water, and with narrow size distribution were successfully obtained. Experimental studies focusing mainly on the effect of process parameters on bead properties were performed. The size of the beads was mainly dependent on the diameter of the membrane pores. High transmembrane pressure made for large gel beads with wide size distribution. Low sodium alginate concentration produced nonspherical beads, whereas a high concentration was unsuitable for the production of small beads with narrow distribution. Thus 1.5% w/v was enough. A high surfactant concentration favored the formation of small beads, but the adverse effect on mass transfer should be considered in this novel process. (C) 2002 Wiley Periodicals, Inc.; With the objective of making calcium alginate gel beads with small and uniform size, membrane emulsification coupled with internal gelation was proposed. Spherical gel beads with mean size of about 50 mum, and even smaller ones in water, and with narrow size distribution were successfully obtained. Experimental studies focusing mainly on the effect of process parameters on bead properties were performed. The size of the beads was mainly dependent on the diameter of the membrane pores. High transmembrane pressure made for large gel beads with wide size distribution. Low sodium alginate concentration produced nonspherical beads, whereas a high concentration was unsuitable for the production of small beads with narrow distribution. Thus 1.5% w/v was enough. A high surfactant concentration favored the formation of small beads, but the adverse effect on mass transfer should be considered in this novel process. (C) 2002 Wiley Periodicals, Inc.
Language英语 ; 英语
URL查看原文 ; 查看原文
WOS IDWOS:000179735700016 ; WOS:000179735700016
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/83375
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Liu, XD,Bao, DC,Xue, WM,et al. Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation, Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation[J]. JOURNAL OF APPLIED POLYMER SCIENCE, JOURNAL OF APPLIED POLYMER SCIENCE,2003, 2003,87, 87(5):848-852, 848-852.
APA Liu, XD.,Bao, DC.,Xue, WM.,Xiong, Y.,Yu, WT.,...&Yuan, Q.(2003).Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation.JOURNAL OF APPLIED POLYMER SCIENCE,87(5),848-852.
MLA Liu, XD,et al."Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation".JOURNAL OF APPLIED POLYMER SCIENCE 87.5(2003):848-852.
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