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题名: DNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices
作者: Oin, JH;  Fung, YS;  Lin, BC
关键词: capillary electrophoresis ;  DNA diagnosis ;  microchip ;  microfluidic ;  mutation ;  SNP ;  STRs
刊名: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
发表日期: 2003-05-01
卷: 3, 期:3, 页:387-394
收录类别: SCI
文章类型: Review
部门归属: 1807
项目归属: 1807
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pathology
研究领域[WOS]: Pathology
英文摘要: DNA diagnosis is experiencing an impressive progression towards the development of novel technology to identity various clinically relevant categories of genetic changes and to meet the exponential growth of genomics. The introduction of capillary electrophoresis has dramatically accelerated the completion of the first draft of the human DNA sequence in the Human Genome Project, and thus, has become the method of choice for analysis of various genetic variants. The recent development of microfabricated electrophoretic devices has led to the possibility of integrating multiple sample handling with the actual measurement steps required for automation of molecular diagnostics. This review highlights the most recent progress in capillary electrophoresis and electrophoretic microdevices for DNA-based diagnostics, including the important areas of genotyping for point mutation, single nucleotide polymorphisms, short tandem repeats and organism identification. The application of these techniques for infectious and genetic disease diagnosis, as well as forensic identification purpose, are covered. The promising development and the challenges for techinical problems are also discussed.
关键词[WOS]: LINEAR POLYACRYLAMIDE SOLUTIONS ;  POLYMERASE-CHAIN-REACTION ;  STRAND CONFORMATION POLYMORPHISM ;  TOTAL ANALYSIS SYSTEMS ;  SHORT TANDEM REPEATS ;  ARRAY ELECTROPHORESIS ;  MICROCHIP ELECTROPHORESIS ;  HIGH-THROUGHPUT ;  1000 BASES ;  HETERODUPLEX ANALYSIS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000188437800010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/83393
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Oin, JH,Fung, YS,Lin, BC. DNA diagnosis by capillary electrophoresis and microfabricated electrophoretic devices[J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS,2003,3(3):387-394.
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