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Synthesis of covalently bonded cellulose derivative chiral stationary phases with a bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate
Chen, XM; Liu, YQ; Qin, F; Kong, L; Zou, HF
KeywordChiral Stationary Phases Lc Enantiomer Separation Cellulose Triethoxysilylpropyl Isocyanate
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2003-08-29
DOI10.1016/S0021-9673(03)01104-X
Volume1010Issue:2Pages:185-194
Indexed BySCI
SubtypeArticle
Department1809
Funding Project1809
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; SILICA-GEL ; POLYSACCHARIDE DERIVATIVES ; ENANTIOMERS ; SEPARATION ; RESOLUTION ; HPLC
AbstractA bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate (TEPI) was initially adopted as a spacer reagent to prepare the bonded types of chiral stationary phases (CSPs) with cellulose derivatives. The silica-based CSPs were chemically prepared with non-regioselective and regioselective approaches and their chiral resolving capabilities were evaluated in terms of HPLC resolution of test enantiomers. It was observed that the chiral recognition capabilities of the non-regioselectively prepared CSPs were influenced by the amount of TEPI used. And also, the regioselectively prepared CSP generally showed a slightly higher resolution power than the non-regioselectively prepared CSP, while the non-regioselective procedures were highly advantageous to rapid preparation. In addition, chiral recognition of the prepared CSPs was affected by the properties of the used silica matrices. (C) 2003 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000185043300005
Citation statistics
Cited Times:64[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/83447
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Chen, XM,Liu, YQ,Qin, F,et al. Synthesis of covalently bonded cellulose derivative chiral stationary phases with a bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate[J]. JOURNAL OF CHROMATOGRAPHY A,2003,1010(2):185-194.
APA Chen, XM,Liu, YQ,Qin, F,Kong, L,&Zou, HF.(2003).Synthesis of covalently bonded cellulose derivative chiral stationary phases with a bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate.JOURNAL OF CHROMATOGRAPHY A,1010(2),185-194.
MLA Chen, XM,et al."Synthesis of covalently bonded cellulose derivative chiral stationary phases with a bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate".JOURNAL OF CHROMATOGRAPHY A 1010.2(2003):185-194.
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