DICP OpenIR
Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers; Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers
Huang, XD; Zou, HF; Chen, XM; Luo, QZ; Kong, L
关键词Molecular Imprinting Molecular Imprinting Stationary Phases Stationary Phases Monolithic Monolithic Lc Lc Enantiomer Separation Enantiomer Separation Diastereomer Separation Diastereomer Separation
刊名JOURNAL OF CHROMATOGRAPHY A ; JOURNAL OF CHROMATOGRAPHY A
2003-01-17 ; 2003-01-17
984期:2页:273-282
收录类别SCI ; SCI
文章类型Article ; Article
部门归属1809 ; 1809
项目归属1809 ; 1809
产权排名1;1 ; 1;1
WOS标题词Science & Technology ; Science & Technology ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Physical Sciences ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Biochemical Research Methods ; Chemistry, Analytical ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Biochemistry & Molecular Biology ; Chemistry ; Chemistry
关键词[WOS]CAPILLARY ELECTROCHROMATOGRAPHY ; CAPILLARY ELECTROCHROMATOGRAPHY ; SUSPENSION POLYMERIZATION ; SUSPENSION POLYMERIZATION ; CHIRAL RECOGNITION ; CHIRAL RECOGNITION ; SOLUTE RETENTION ; SOLUTE RETENTION ; AFFINITY MEDIA ; AFFINITY MEDIA ; POLYMERS ; POLYMERS ; SELECTIVITY ; SELECTIVITY ; PERFLUOROCARBON ; PERFLUOROCARBON ; TEMPLATE ; TEMPLATE ; BEADS ; BEADS
英文摘要The method for preparation of molecularly imprinted monolithic stationary phase has been improved to achieve liquid chromatographic separation of enantiomers and diastereomers. By adopting low polar porogenic solvents of toluene and dodecanol and optimal polymerization conditions, the molecularly imprinted monolithic stationary phases with good flow-through properties and high resolution were prepared. Enantiomers of amino acid derivatives and diastereomers of cinchona alkaloids were completely resolved using the monolithic stationary phases. The influence of porogenic composition, monomer-template ratio and polymerization conditions on the chromatographic performance was investigated. Some chromatographic conditions such as the composition of the mobile phase and the temperature were characterized. Scanning electron microscopy showed that the molecularly imprinted monolithic stationary phase has a large through-pore structure to allow the mobile phase to flow through the column at very low backpressure. Accelerated separations of enantiomers and diastereomers were therefore achieved at elevated flow rates. Finally, the chiral recognition performance of the prepared stationary phase in aqueous media was investigated. Hydrophobic interaction, and ionic and/or hydrogen bonding interactions were proposed to be responsible for the recognition mechanism. (C) 2002 Elsevier Science B.V. All rights reserved.; The method for preparation of molecularly imprinted monolithic stationary phase has been improved to achieve liquid chromatographic separation of enantiomers and diastereomers. By adopting low polar porogenic solvents of toluene and dodecanol and optimal polymerization conditions, the molecularly imprinted monolithic stationary phases with good flow-through properties and high resolution were prepared. Enantiomers of amino acid derivatives and diastereomers of cinchona alkaloids were completely resolved using the monolithic stationary phases. The influence of porogenic composition, monomer-template ratio and polymerization conditions on the chromatographic performance was investigated. Some chromatographic conditions such as the composition of the mobile phase and the temperature were characterized. Scanning electron microscopy showed that the molecularly imprinted monolithic stationary phase has a large through-pore structure to allow the mobile phase to flow through the column at very low backpressure. Accelerated separations of enantiomers and diastereomers were therefore achieved at elevated flow rates. Finally, the chiral recognition performance of the prepared stationary phase in aqueous media was investigated. Hydrophobic interaction, and ionic and/or hydrogen bonding interactions were proposed to be responsible for the recognition mechanism. (C) 2002 Elsevier Science B.V. All rights reserved.
语种英语 ; 英语
原文出处查看原文 ; 查看原文
WOS记录号WOS:000180309800013 ; WOS:000180309800013
引用统计
被引频次:136[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/83449
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
推荐引用方式
GB/T 7714
Huang, XD,Zou, HF,Chen, XM,et al. Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers, Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers[J]. JOURNAL OF CHROMATOGRAPHY A, JOURNAL OF CHROMATOGRAPHY A,2003, 2003,984, 984(2):273-282, 273-282.
APA Huang, XD,Zou, HF,Chen, XM,Luo, QZ,&Kong, L.(2003).Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers.JOURNAL OF CHROMATOGRAPHY A,984(2),273-282.
MLA Huang, XD,et al."Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers".JOURNAL OF CHROMATOGRAPHY A 984.2(2003):273-282.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2003H9W3J56564.pdf(537KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, XD]的文章
[Zou, HF]的文章
[Chen, XM]的文章
百度学术
百度学术中相似的文章
[Huang, XD]的文章
[Zou, HF]的文章
[Chen, XM]的文章
必应学术
必应学术中相似的文章
[Huang, XD]的文章
[Zou, HF]的文章
[Chen, XM]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。