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题名: Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers
作者: Huang, XD;  Zou, HF;  Chen, XM;  Luo, QZ;  Kong, L
关键词: molecular imprinting ;  stationary phases ;  monolithic ;  LC ;  enantiomer separation ;  diastereomer separation
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2003-01-17
卷: 984, 期:2, 页:273-282
收录类别: SCI
文章类型: Article
部门归属: 1809
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The method for preparation of molecularly imprinted monolithic stationary phase has been improved to achieve liquid chromatographic separation of enantiomers and diastereomers. By adopting low polar porogenic solvents of toluene and dodecanol and optimal polymerization conditions, the molecularly imprinted monolithic stationary phases with good flow-through properties and high resolution were prepared. Enantiomers of amino acid derivatives and diastereomers of cinchona alkaloids were completely resolved using the monolithic stationary phases. The influence of porogenic composition, monomer-template ratio and polymerization conditions on the chromatographic performance was investigated. Some chromatographic conditions such as the composition of the mobile phase and the temperature were characterized. Scanning electron microscopy showed that the molecularly imprinted monolithic stationary phase has a large through-pore structure to allow the mobile phase to flow through the column at very low backpressure. Accelerated separations of enantiomers and diastereomers were therefore achieved at elevated flow rates. Finally, the chiral recognition performance of the prepared stationary phase in aqueous media was investigated. Hydrophobic interaction, and ionic and/or hydrogen bonding interactions were proposed to be responsible for the recognition mechanism. (C) 2002 Elsevier Science B.V. All rights reserved.
关键词[WOS]: CAPILLARY ELECTROCHROMATOGRAPHY ;  SUSPENSION POLYMERIZATION ;  CHIRAL RECOGNITION ;  SOLUTE RETENTION ;  AFFINITY MEDIA ;  POLYMERS ;  SELECTIVITY ;  PERFLUOROCARBON ;  TEMPLATE ;  BEADS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000180309800013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/83449
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Huang, XD,Zou, HF,Chen, XM,et al. Molecularly imprinted monolithic stationary phases for liquid chromatographic separation of enantiomers and diastereomers[J]. JOURNAL OF CHROMATOGRAPHY A,2003,984(2):273-282.
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