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Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent
Koppenhoefer, B; Jakob, A; Zhu, XF; Lin, BC
关键词Capillary Electrophoresis Enantiomer Separation Chiral Drugs Tm-gamma-cyclodextrin
刊名HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY
2000-06-01
23期:6页:413-429
收录类别SCI
文章类型Article
部门归属4
项目归属401
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]HYDROXYPROPYL-BETA-CYCLODEXTRIN ; ZONE ELECTROPHORESIS ; BASIC DRUGS ; ELECTROKINETIC CHROMATOGRAPHY ; ALPHA-CYCLODEXTRIN ; AMINO-ALCOHOLS ; RESOLUTION ; PARAMETERS ; ADDITIVES ; PHASE
英文摘要High-throughput screening is a promising new approach in analytical chemistry. Within the framework of an extended screening program (The German-Chinese Drug Screening Program), the enantioseparation of 86 drugs was investigated by capillary zone electrophoresis in the presence of the chiral solvating agent (CSA) octakis-(2,3,6-tri-O-methyl)-gamma-cyclodextrin (TM-gamma-CD). By this means, 15 drugs could be separated into enantiomeric pairs. Approximate measures for the degree of interaction (migration retardation factor, R-m) and for the degree of enantiomer recognition (migration separation factors, alpha(m)) revealed intriguing patterns that were compared with those found for native gamma-cyclodextrin (gamma-CD). Although there is a distinct influence of the analyte structure on the electrophoretic data, interpretation remains difficult. Most remarkably, permethylation of gamma-CD leads neither to a higher affinity nor to better chiral recognition, in contrast to the findings with alpha-CD.
语种英语
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WOS记录号WOS:000088042800002
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/84003
专题中国科学院大连化学物理研究所
作者单位1.Univ Tubingen, Inst Organ Chem, D-72074 Tubingen, Germany
2.Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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GB/T 7714
Koppenhoefer, B,Jakob, A,Zhu, XF,et al. Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent[J]. HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,2000,23(6):413-429.
APA Koppenhoefer, B,Jakob, A,Zhu, XF,&Lin, BC.(2000).Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent.HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,23(6),413-429.
MLA Koppenhoefer, B,et al."Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent".HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY 23.6(2000):413-429.
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