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题名: Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent
作者: Koppenhoefer, B;  Jakob, A;  Zhu, XF;  Lin, BC
关键词: capillary electrophoresis ;  enantiomer separation ;  chiral drugs ;  TM-gamma-cyclodextrin
刊名: HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY
发表日期: 2000-06-01
卷: 23, 期:6, 页:413-429
收录类别: SCI
文章类型: Article
部门归属: 4
项目归属: 401
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: High-throughput screening is a promising new approach in analytical chemistry. Within the framework of an extended screening program (The German-Chinese Drug Screening Program), the enantioseparation of 86 drugs was investigated by capillary zone electrophoresis in the presence of the chiral solvating agent (CSA) octakis-(2,3,6-tri-O-methyl)-gamma-cyclodextrin (TM-gamma-CD). By this means, 15 drugs could be separated into enantiomeric pairs. Approximate measures for the degree of interaction (migration retardation factor, R-m) and for the degree of enantiomer recognition (migration separation factors, alpha(m)) revealed intriguing patterns that were compared with those found for native gamma-cyclodextrin (gamma-CD). Although there is a distinct influence of the analyte structure on the electrophoretic data, interpretation remains difficult. Most remarkably, permethylation of gamma-CD leads neither to a higher affinity nor to better chiral recognition, in contrast to the findings with alpha-CD.
关键词[WOS]: HYDROXYPROPYL-BETA-CYCLODEXTRIN ;  ZONE ELECTROPHORESIS ;  BASIC DRUGS ;  ELECTROKINETIC CHROMATOGRAPHY ;  ALPHA-CYCLODEXTRIN ;  AMINO-ALCOHOLS ;  RESOLUTION ;  PARAMETERS ;  ADDITIVES ;  PHASE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000088042800002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84003
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, Inst Organ Chem, D-72074 Tubingen, Germany
2.Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Koppenhoefer, B,Jakob, A,Zhu, XF,et al. Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent[J]. HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,2000,23(6):413-429.
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