DICP OpenIR
Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent
Koppenhoefer, B; Jakob, A; Zhu, XF; Lin, BC
KeywordCapillary Electrophoresis Enantiomer Separation Chiral Drugs Tm-gamma-cyclodextrin
Source PublicationHRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY
2000-06-01
Volume23Issue:6Pages:413-429
Indexed BySCI
SubtypeArticle
Department4
Funding Project401
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordHYDROXYPROPYL-BETA-CYCLODEXTRIN ; ZONE ELECTROPHORESIS ; BASIC DRUGS ; ELECTROKINETIC CHROMATOGRAPHY ; ALPHA-CYCLODEXTRIN ; AMINO-ALCOHOLS ; RESOLUTION ; PARAMETERS ; ADDITIVES ; PHASE
AbstractHigh-throughput screening is a promising new approach in analytical chemistry. Within the framework of an extended screening program (The German-Chinese Drug Screening Program), the enantioseparation of 86 drugs was investigated by capillary zone electrophoresis in the presence of the chiral solvating agent (CSA) octakis-(2,3,6-tri-O-methyl)-gamma-cyclodextrin (TM-gamma-CD). By this means, 15 drugs could be separated into enantiomeric pairs. Approximate measures for the degree of interaction (migration retardation factor, R-m) and for the degree of enantiomer recognition (migration separation factors, alpha(m)) revealed intriguing patterns that were compared with those found for native gamma-cyclodextrin (gamma-CD). Although there is a distinct influence of the analyte structure on the electrophoretic data, interpretation remains difficult. Most remarkably, permethylation of gamma-CD leads neither to a higher affinity nor to better chiral recognition, in contrast to the findings with alpha-CD.
Language英语
URL查看原文
WOS IDWOS:000088042800002
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/84003
Collection中国科学院大连化学物理研究所
Affiliation1.Univ Tubingen, Inst Organ Chem, D-72074 Tubingen, Germany
2.Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Koppenhoefer, B,Jakob, A,Zhu, XF,et al. Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent[J]. HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,2000,23(6):413-429.
APA Koppenhoefer, B,Jakob, A,Zhu, XF,&Lin, BC.(2000).Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent.HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,23(6),413-429.
MLA Koppenhoefer, B,et al."Separation of enantiomers of drugs by capillary electrophoresis with permethyl-gamma-cyclodextrin as chiral solvating agent".HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY 23.6(2000):413-429.
Files in This Item:
File Name/Size DocType Version Access License
20003B945E33Q6.pdf(376KB) 开放获取--Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Koppenhoefer, B]'s Articles
[Jakob, A]'s Articles
[Zhu, XF]'s Articles
Baidu academic
Similar articles in Baidu academic
[Koppenhoefer, B]'s Articles
[Jakob, A]'s Articles
[Zhu, XF]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Koppenhoefer, B]'s Articles
[Jakob, A]'s Articles
[Zhu, XF]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.