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题名: Study of normal and modified nucleosides in serum by RP-HPLC
作者: Xu, G;  Enderle, H;  Liebich, H;  Lu, P
关键词: column liquid chromatography ;  nucleosides in serum ;  tumor markers ;  factor analysis
刊名: CHROMATOGRAPHIA
发表日期: 2000-08-01
卷: 52, 期:3-4, 页:152-158
收录类别: SCI
文章类型: Article
部门归属: 4
项目归属: 402
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Modified nucleosides derived predominantly from transfer ribonucleic acid (tRNA) have been studied as possible tumor markers. In this paper a reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been applied to study 15 normal and modified nucleosides in serum. The nucleoside levels in normal human serum were established, and the concentrations of 15 nucleosides in serum from 19 cancer patients were determined, it was found that the concentrations of modified nucleosides were significantly higher in patient sera. Based on 15 nucleoside concentrations in serum, factor analysis could classify correctly 90% of cancer patients from the normal humans Further work showed that urine was slightly better than serum when determining nucleosides as biological marker candidates. More work is ongoing to determine the clinical usefulness of modified nucleosides as tumor markers.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  PLACENTAL ALKALINE-PHOSPHATASE ;  URINARY MODIFIED NUCLEOSIDES ;  CANCER-PATIENTS ;  TUMOR-MARKERS ;  TRANSFER-RNA ;  CAPILLARY-ELECTROPHORESIS ;  CARCINOEMBRYONIC ANTIGEN ;  MONOCLONAL-ANTIBODIES ;  PSEUDOURIDINE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000088867200005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84015
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Univ Tubingen, Med Klin, D-72076 Tubingen, Germany

Recommended Citation:
Xu, G,Enderle, H,Liebich, H,et al. Study of normal and modified nucleosides in serum by RP-HPLC[J]. CHROMATOGRAPHIA,2000,52(3-4):152-158.
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