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Study of normal and modified nucleosides in serum by RP-HPLC
Xu, G; Enderle, H; Liebich, H; Lu, P
KeywordColumn Liquid Chromatography Nucleosides In Serum Tumor Markers Factor Analysis
Source PublicationCHROMATOGRAPHIA
2000-08-01
Volume52Issue:3-4Pages:152-158
Indexed BySCI
SubtypeArticle
Department4
Funding Project402
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; PLACENTAL ALKALINE-PHOSPHATASE ; URINARY MODIFIED NUCLEOSIDES ; CANCER-PATIENTS ; TUMOR-MARKERS ; TRANSFER-RNA ; CAPILLARY-ELECTROPHORESIS ; CARCINOEMBRYONIC ANTIGEN ; MONOCLONAL-ANTIBODIES ; PSEUDOURIDINE
AbstractModified nucleosides derived predominantly from transfer ribonucleic acid (tRNA) have been studied as possible tumor markers. In this paper a reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been applied to study 15 normal and modified nucleosides in serum. The nucleoside levels in normal human serum were established, and the concentrations of 15 nucleosides in serum from 19 cancer patients were determined, it was found that the concentrations of modified nucleosides were significantly higher in patient sera. Based on 15 nucleoside concentrations in serum, factor analysis could classify correctly 90% of cancer patients from the normal humans Further work showed that urine was slightly better than serum when determining nucleosides as biological marker candidates. More work is ongoing to determine the clinical usefulness of modified nucleosides as tumor markers.
Language英语
URL查看原文
WOS IDWOS:000088867200005
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/84015
Collection中国科学院大连化学物理研究所
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Univ Tubingen, Med Klin, D-72076 Tubingen, Germany
Recommended Citation
GB/T 7714
Xu, G,Enderle, H,Liebich, H,et al. Study of normal and modified nucleosides in serum by RP-HPLC[J]. CHROMATOGRAPHIA,2000,52(3-4):152-158.
APA Xu, G,Enderle, H,Liebich, H,&Lu, P.(2000).Study of normal and modified nucleosides in serum by RP-HPLC.CHROMATOGRAPHIA,52(3-4),152-158.
MLA Xu, G,et al."Study of normal and modified nucleosides in serum by RP-HPLC".CHROMATOGRAPHIA 52.3-4(2000):152-158.
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