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Study of normal and modified nucleosides in serum by RP-HPLC
Xu, G; Enderle, H; Liebich, H; Lu, P
关键词Column Liquid Chromatography Nucleosides In Serum Tumor Markers Factor Analysis
刊名CHROMATOGRAPHIA
2000-08-01
52期:3-4页:152-158
收录类别SCI
文章类型Article
部门归属4
项目归属402
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; PLACENTAL ALKALINE-PHOSPHATASE ; URINARY MODIFIED NUCLEOSIDES ; CANCER-PATIENTS ; TUMOR-MARKERS ; TRANSFER-RNA ; CAPILLARY-ELECTROPHORESIS ; CARCINOEMBRYONIC ANTIGEN ; MONOCLONAL-ANTIBODIES ; PSEUDOURIDINE
英文摘要Modified nucleosides derived predominantly from transfer ribonucleic acid (tRNA) have been studied as possible tumor markers. In this paper a reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been applied to study 15 normal and modified nucleosides in serum. The nucleoside levels in normal human serum were established, and the concentrations of 15 nucleosides in serum from 19 cancer patients were determined, it was found that the concentrations of modified nucleosides were significantly higher in patient sera. Based on 15 nucleoside concentrations in serum, factor analysis could classify correctly 90% of cancer patients from the normal humans Further work showed that urine was slightly better than serum when determining nucleosides as biological marker candidates. More work is ongoing to determine the clinical usefulness of modified nucleosides as tumor markers.
语种英语
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WOS记录号WOS:000088867200005
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/84015
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Univ Tubingen, Med Klin, D-72076 Tubingen, Germany
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GB/T 7714
Xu, G,Enderle, H,Liebich, H,et al. Study of normal and modified nucleosides in serum by RP-HPLC[J]. CHROMATOGRAPHIA,2000,52(3-4):152-158.
APA Xu, G,Enderle, H,Liebich, H,&Lu, P.(2000).Study of normal and modified nucleosides in serum by RP-HPLC.CHROMATOGRAPHIA,52(3-4),152-158.
MLA Xu, G,et al."Study of normal and modified nucleosides in serum by RP-HPLC".CHROMATOGRAPHIA 52.3-4(2000):152-158.
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