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题名: Excretion pattern investigation of urinary normal and modified nucleosides of breast cancer patients by RP-HPLC and factor analysis method
作者: Xu, G;  Schmid, HR;  Lu, X;  Liebich, HM;  Lu, P
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2000-11-01
卷: 14, 期:7, 页:459-463
收录类别: SCI
文章类型: Article
部门归属: 4
项目归属: 402
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Biochemistry & Molecular Biology ;  Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Pharmacology & Pharmacy
英文摘要: Modified nucleosides, formed post-transcriptionally in RNA by a number of modification enzymes, are excreted in abnormal levels in the urine of patients with malignant tumors. To test their usefulness as tumor markers, and to compare them with the conventional tumor markers, a reversed-phase high-performance liquid chromatographic (RP-HPLC) method and a factor analysis method have been used to study the excretion pattern of nucleosides of breast cancer patients. A clear cut differentiation of the breast cancer group and the healthy individuals in two clusters without overlapping was obtained. Copyright (C) 2000 John Wiley & Sons, Ltd.
关键词[WOS]: CAPILLARY-ELECTROPHORESIS ;  PSEUDOURIDINE ;  CARCINOMA ;  PROTEIN ;  MARKERS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000165458200002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84029
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Med Univ Klin, D-72076 Tubingen, Germany

Recommended Citation:
Xu, G,Schmid, HR,Lu, X,et al. Excretion pattern investigation of urinary normal and modified nucleosides of breast cancer patients by RP-HPLC and factor analysis method[J]. BIOMEDICAL CHROMATOGRAPHY,2000,14(7):459-463.
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