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Multivariate optimization in micellar electrokinetic capillary chromatography
Lee, RJ; Liu, Z; Zou, HF; Ni, JY; Zhang, YK
关键词Uniform Design Iterative Optimization Aromatic Compounds Mecc Organic Modifiers
刊名JOURNAL OF MICROCOLUMN SEPARATIONS
2000-06-01
12期:6页:356-365
收录类别SCI
文章类型Article
部门归属4
项目归属403
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]RESOLUTION MAPPING SCHEME ; ORGANIC MODIFIERS ; MOBILE PHASE ; SEPARATION ; SELECTIVITY ; SULFONAMIDES ; UREA
英文摘要The optimization of the organic modifier concentration in micellar electrokinetic capillary chromatography (MECC) has been achieved by a uniform design and iterative optimization method, which has been developed for the optimization of composition of the mobile phase in high performance liquid chromatography. According to the proposed method, the uniform design technique has been applied to design the starting experiments, which can reduce the number of experiments compared with traditional simultaneous methods, such as the orthano design. The hierarchical chromatographic response function has been modified to evaluate the separation quality of a chromatogram in MECC. An iterative procedure has been adopted to search the optimal concentration of organic modifiers for improving the accuracy of retention predicted and the quality of the chromatogram. Validity of the optimization method has been proved by the separation of 31 aromatic compounds in MECC. (C) 2000 John Wiley & Sons, Inc.
语种英语
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WOS记录号WOS:000087951900004
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/84041
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
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GB/T 7714
Lee, RJ,Liu, Z,Zou, HF,et al. Multivariate optimization in micellar electrokinetic capillary chromatography[J]. JOURNAL OF MICROCOLUMN SEPARATIONS,2000,12(6):356-365.
APA Lee, RJ,Liu, Z,Zou, HF,Ni, JY,&Zhang, YK.(2000).Multivariate optimization in micellar electrokinetic capillary chromatography.JOURNAL OF MICROCOLUMN SEPARATIONS,12(6),356-365.
MLA Lee, RJ,et al."Multivariate optimization in micellar electrokinetic capillary chromatography".JOURNAL OF MICROCOLUMN SEPARATIONS 12.6(2000):356-365.
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