DICP OpenIR
Multivariate optimization in micellar electrokinetic capillary chromatography
Lee, RJ; Liu, Z; Zou, HF; Ni, JY; Zhang, YK
KeywordUniform Design Iterative Optimization Aromatic Compounds Mecc Organic Modifiers
Source PublicationJOURNAL OF MICROCOLUMN SEPARATIONS
2000-06-01
Volume12Issue:6Pages:356-365
Indexed BySCI
SubtypeArticle
Department4
Funding Project403
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordRESOLUTION MAPPING SCHEME ; ORGANIC MODIFIERS ; MOBILE PHASE ; SEPARATION ; SELECTIVITY ; SULFONAMIDES ; UREA
AbstractThe optimization of the organic modifier concentration in micellar electrokinetic capillary chromatography (MECC) has been achieved by a uniform design and iterative optimization method, which has been developed for the optimization of composition of the mobile phase in high performance liquid chromatography. According to the proposed method, the uniform design technique has been applied to design the starting experiments, which can reduce the number of experiments compared with traditional simultaneous methods, such as the orthano design. The hierarchical chromatographic response function has been modified to evaluate the separation quality of a chromatogram in MECC. An iterative procedure has been adopted to search the optimal concentration of organic modifiers for improving the accuracy of retention predicted and the quality of the chromatogram. Validity of the optimization method has been proved by the separation of 31 aromatic compounds in MECC. (C) 2000 John Wiley & Sons, Inc.
Language英语
URL查看原文
WOS IDWOS:000087951900004
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/84041
Collection中国科学院大连化学物理研究所
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Lee, RJ,Liu, Z,Zou, HF,et al. Multivariate optimization in micellar electrokinetic capillary chromatography[J]. JOURNAL OF MICROCOLUMN SEPARATIONS,2000,12(6):356-365.
APA Lee, RJ,Liu, Z,Zou, HF,Ni, JY,&Zhang, YK.(2000).Multivariate optimization in micellar electrokinetic capillary chromatography.JOURNAL OF MICROCOLUMN SEPARATIONS,12(6),356-365.
MLA Lee, RJ,et al."Multivariate optimization in micellar electrokinetic capillary chromatography".JOURNAL OF MICROCOLUMN SEPARATIONS 12.6(2000):356-365.
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