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题名: Multivariate optimization in micellar electrokinetic capillary chromatography
作者: Lee, RJ;  Liu, Z;  Zou, HF;  Ni, JY;  Zhang, YK
关键词: uniform design ;  iterative optimization ;  aromatic compounds ;  MECC ;  organic modifiers
刊名: JOURNAL OF MICROCOLUMN SEPARATIONS
发表日期: 2000-06-01
卷: 12, 期:6, 页:356-365
收录类别: SCI
文章类型: Article
部门归属: 4
项目归属: 403
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: The optimization of the organic modifier concentration in micellar electrokinetic capillary chromatography (MECC) has been achieved by a uniform design and iterative optimization method, which has been developed for the optimization of composition of the mobile phase in high performance liquid chromatography. According to the proposed method, the uniform design technique has been applied to design the starting experiments, which can reduce the number of experiments compared with traditional simultaneous methods, such as the orthano design. The hierarchical chromatographic response function has been modified to evaluate the separation quality of a chromatogram in MECC. An iterative procedure has been adopted to search the optimal concentration of organic modifiers for improving the accuracy of retention predicted and the quality of the chromatogram. Validity of the optimization method has been proved by the separation of 31 aromatic compounds in MECC. (C) 2000 John Wiley & Sons, Inc.
关键词[WOS]: RESOLUTION MAPPING SCHEME ;  ORGANIC MODIFIERS ;  MOBILE PHASE ;  SEPARATION ;  SELECTIVITY ;  SULFONAMIDES ;  UREA
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000087951900004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84041
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Lee, RJ,Liu, Z,Zou, HF,et al. Multivariate optimization in micellar electrokinetic capillary chromatography[J]. JOURNAL OF MICROCOLUMN SEPARATIONS,2000,12(6):356-365.
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