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题名: Capillary electrophoresis of urinary normal and modified nucleosides of cancer patients
作者: Liebich, HM;  Xu, G;  Di Stefano, C;  Lehmann, R
关键词: nucleosides
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 1998-01-16
卷: 793, 期:2, 页:341-347
收录类别: ISTP ;  SCI
文章类型: Article
部门归属: 4
项目归属: 402
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: This paper gives a capillary electrophoretic method for the separation of 15 urinary normal and modified nucleosides from cancer patients in less than 40 min. A 500 mmx50 mu m uncoated capillary column (437.5 mm to window) was used. The effects of the voltage and the sodium dodecyl sulfate (SDS) concentration in the buffer on the separation were studied. With reproducibilities of migration times better than 1.2% (R.S.D.) and determined concentrations better than 5-25%, depending on the concentrations of nucleosides in the urine, the analytical characteristics of the method were food. Using this developed method, the concentrations of 13 normal and modified nucleosides, extracted on a phenyl boronic acid affinity chromatography column, in 25 urines from patients of 14 kinds of cancer were determined. The levels (nmol/mol creatinine) of modified nucleosides in urines from cancer patients were increased as compared with those in normal urines. (C) 1998 Elsevier Science B.V.
关键词[WOS]: PLACENTAL ALKALINE-PHOSPHATASE ;  TISSUE POLYPEPTIDE ANTIGEN ;  SMALL CELL-CARCINOMA ;  TUMOR-MARKERS ;  CARCINOEMBRYONIC ANTIGEN ;  TRANSFER-RNA ;  MONOCLONAL-ANTIBODIES ;  BIOLOGICAL MARKERS ;  RIBONUCLEIC-ACID ;  EXCRETION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000071668800013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84045
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, Med Klin, Abt 4, Dept Clin Chem, D-72076 Tubingen, Germany
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Liebich, HM,Xu, G,Di Stefano, C,et al. Capillary electrophoresis of urinary normal and modified nucleosides of cancer patients[J]. JOURNAL OF CHROMATOGRAPHY A,1998,793(2):341-347.
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