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题名: A method for the analysis of low-mass molecules by MALDI-TOF mass spectrometry
作者: Guo, Z;  Zhang, QC;  Zou, HF;  Guo, BC;  Ni, JY
刊名: ANALYTICAL CHEMISTRY
发表日期: 2002-04-01
DOI: 10.1021/ac010979m
卷: 74, 期:7, 页:1637-1641
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: We report a novel method termed matrix suppressed laser desorption/ionization to improve the analysis of low-mass molecules by MALDI-TOF mass spectrometry. In this method, the surfactant of cetrimonium bromide (CTAB) is added to the conventional matrix of alpha-cyano-4-hydroxycinnamic acid solution to prepare the MALDI samples. During the MALDI process, the presence of CTAB could substantially or even completely suppress the matrix-related ion background. As a result, very clean mass spectra can be routinely obtained in the low-mass range. In addition, the presence of CTAB can significantly improve the mass resolution of low-mass molecules. It is seen that high-quality spectra were routinely obtained at a matrix/CTAB ratio of 1000:1. This method has been successfully used to analyze a variety of low-mass molecules.
关键词[WOS]: ASSISTED-LASER-DESORPTION/IONIZATION ;  SAMPLE PREPARATION ;  MATRIX ;  TIME ;  SUPPRESSION ;  DESORPTION ;  IONS ;  IONIZATION ;  PEPTIDES ;  PROTEINS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000174841600035
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84211
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Cleveland State Univ, Dept Chem, Cleveland, OH 44115 USA

Recommended Citation:
Guo, Z,Zhang, QC,Zou, HF,et al. A method for the analysis of low-mass molecules by MALDI-TOF mass spectrometry[J]. ANALYTICAL CHEMISTRY,2002,74(7):1637-1641.
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