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Total analytical method for Radix astragali extract using two-binary multi-segment gradient elution liquid chromatography
Xiao, HB; Liang, XM; Lu, PC
关键词Column Liquid Chromatography Method Development Computer Simulation Gradient Optimization Radix Astragali Complex Sample
刊名JOURNAL OF SEPARATION SCIENCE
2001-03-01
24期:3页:186-196
收录类别SCI
文章类型Article
部门归属18027
项目归属1804
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]OPTIMIZING TEMPERATURE ; COMPLEX SAMPLES ; OPTIMIZATION ; SEPARATION ; CONSTITUENTS ; TANG
英文摘要There is an urgent need for thorough analysis of Radix astragali, a widely used Chinese herb, for quality control purposes. This paper describes the development of a total analytical method for Radix astragali extract, a multi-component complex mixture. Twenty-four components were separated step by step from the extract using a series of isocratic isopropanol-methanol elutions, and then 42 components were separated similarly using methanol-water elutions. Based on the log k(w) and -S of the 66 components obtained from the above procedure and the optimization software developed in our laboratory, an optimum elution program consisting of seven methanol-water segments and four isopropanol-methanol segments was developed to finish the task of analyzing the total components in a single run. Under optimized gradient conditions, the sample of Radix astragali extract was analyzed. As expected, most of the components were well separated and the experimental chromatogram was in a good agreement with the predicted one.
语种英语
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WOS记录号WOS:000167947800005
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/84617
专题中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
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Xiao, HB,Liang, XM,Lu, PC. Total analytical method for Radix astragali extract using two-binary multi-segment gradient elution liquid chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2001,24(3):186-196.
APA Xiao, HB,Liang, XM,&Lu, PC.(2001).Total analytical method for Radix astragali extract using two-binary multi-segment gradient elution liquid chromatography.JOURNAL OF SEPARATION SCIENCE,24(3),186-196.
MLA Xiao, HB,et al."Total analytical method for Radix astragali extract using two-binary multi-segment gradient elution liquid chromatography".JOURNAL OF SEPARATION SCIENCE 24.3(2001):186-196.
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