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题名: Total analytical method for Radix astragali extract using two-binary multi-segment gradient elution liquid chromatography
作者: Xiao, HB;  Liang, XM;  Lu, PC
关键词: column liquid chromatography ;  method development ;  computer simulation ;  gradient optimization ;  Radix astragali ;  complex sample
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2001-03-01
卷: 24, 期:3, 页:186-196
收录类别: SCI
文章类型: Article
部门归属: 18027
项目归属: 1804
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: There is an urgent need for thorough analysis of Radix astragali, a widely used Chinese herb, for quality control purposes. This paper describes the development of a total analytical method for Radix astragali extract, a multi-component complex mixture. Twenty-four components were separated step by step from the extract using a series of isocratic isopropanol-methanol elutions, and then 42 components were separated similarly using methanol-water elutions. Based on the log k(w) and -S of the 66 components obtained from the above procedure and the optimization software developed in our laboratory, an optimum elution program consisting of seven methanol-water segments and four isopropanol-methanol segments was developed to finish the task of analyzing the total components in a single run. Under optimized gradient conditions, the sample of Radix astragali extract was analyzed. As expected, most of the components were well separated and the experimental chromatogram was in a good agreement with the predicted one.
关键词[WOS]: OPTIMIZING TEMPERATURE ;  COMPLEX SAMPLES ;  OPTIMIZATION ;  SEPARATION ;  CONSTITUENTS ;  TANG
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000167947800005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84617
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China

Recommended Citation:
Xiao, HB,Liang, XM,Lu, PC. Total analytical method for Radix astragali extract using two-binary multi-segment gradient elution liquid chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2001,24(3):186-196.
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