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题名: Determination of sialic acids in the serum of cancer patients by capillary electrophoresis
作者: Dong, XL;  Xu, X;  Han, F;  Ping, XY;  Yuang, XL;  Lin, BC
关键词: capillary electrophoresis ;  sialic acids ;  cancer patients
刊名: ELECTROPHORESIS
发表日期: 2001-07-01
卷: 22, 期:11, 页:2231-2235
收录类别: ISTP ;  SCI
文章类型: Article
部门归属: 18042
项目归属: 1807
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A novel method for the determination of N-acetylneuraminic acid (NANA) and N-glycolylneuraminic acid (NGNA) was developed by using high-performance capillary electrophoresis (HPCE) with UV detection at 195 nm. NANA and NGNA were separated directly and analyzed without pre- or postcolumn derivation. The detection limit of NANA is 9.6 x 10(-6) mol L-1 and for mass 3.879 x 10(-14) mol (39 fmol). This method was applied for the determination of NANA in 30 normal human and 72 cancer patients. The results demonstrated that NANA in the sera of cancer patients increased significantly as compared with the normal human (P < 0.001). The new method is simple and sensitive, and is suitable for basic research and clinical application to malignant tumors.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  N-GLYCOLYLNEURAMINIC ACIDS ;  ACETYLNEURAMINIC ACID ;  ULTRAVIOLET DETECTION ;  GLYCOPROTEINS ;  DERIVATIZATION ;  ACETYL
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000170175800016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/84629
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Dalian Third Minicipal Hosp, Dalian, Peoples R China
3.Dalian Obstet & Gynecol Hosp, Dalian, Peoples R China
4.Dalian Med Univ, Dalian, Peoples R China

Recommended Citation:
Dong, XL,Xu, X,Han, F,et al. Determination of sialic acids in the serum of cancer patients by capillary electrophoresis[J]. ELECTROPHORESIS,2001,22(11):2231-2235.
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