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题名: Alternative splicing of the FMR1 gene in human tissues of fetal and adult
作者: Kan, D;  Li, LY;  Fan, Y;  Xu, Q;  Han, FT;  Zhu, NN;  Liu, EL;  Lin, BC;  Wu, GY;  Shen, Y
关键词: FMR1 ;  transcription ;  alternative splicing ;  capillary electrophoresis
刊名: PROGRESS IN NATURAL SCIENCE
发表日期: 1999-05-01
卷: 9, 期:5, 页:367-373
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Multidisciplinary ;  Multidisciplinary Sciences
研究领域[WOS]: Materials Science ;  Science & Technology - Other Topics
英文摘要: To study the time- and tissue-specificity of alternative splicing of the FMR1 gene, we analyzed the alternative splicing pattern of the FMR1 gene in human tissues from adult and fetus using RT-PCR coupled with capillary electrophoresis. Seven alternative splicing variants of FMR1 were found in adult liver and lung. The major three alternative splicing variants of the FMR1 gene in all analyzed fetal tissues were same, though the number of minor isoforms and the relative abundance of major isoforms were different. The major difference of the alternative splicing pat tem between adult and fetus was in exon 12 and 17. The results suggest that the alternative splicing pattern of the FMR1 gene is non-tissue-specific in the same developmental stage and a developmental switch may be present.
关键词[WOS]: FRAGILE-X SYNDROME ;  MENTAL-RETARDATION PROTEIN ;  CAPILLARY ELECTROPHORESIS ;  RNA-BINDING ;  KH DOMAINS ;  LOCALIZATION ;  EXPRESSION ;  BRAIN
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000080568900007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/86199
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China
2.Tianjin Med Univ, Inst Endocrinol, Tianjin 300070, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Kan, D,Li, LY,Fan, Y,et al. Alternative splicing of the FMR1 gene in human tissues of fetal and adult[J]. PROGRESS IN NATURAL SCIENCE,1999,9(5):367-373.
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