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题名: Optimization and parameter study for chiral separation by capillary electrophoresis
作者: Zhu, XF;  Lin, BC;  Jakob, A;  Epperlein, U;  Koppenhoefer, B
关键词: capillary electrophoresis ;  experimental design ;  cyclodextrin ;  chiral separation
刊名: HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY
发表日期: 1999-08-01
卷: 22, 期:8, 页:449-453
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Orthogonal design and uniform design were used for the optimization of separation of enantiomers using 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CD) as a chiral selector by capillary zone electrophoresis, The concentration of DM-beta-CD, buffer pH, running voltage, and capillary temperature were selected as variable parameters, their different effects on peak resolution were studied by the design methods. It was concluded that orthogonal design offers a rapid and efficient means for testing the importance of individual parameters and for determining the optimum operating conditions. However, for a large number of both factors and levels, uniform design is more efficient, The effect of addition of methanol and citric acid buffer on the separation of enantiomers was also examined.
关键词[WOS]: MICELLAR ELECTROKINETIC CHROMATOGRAPHY ;  PERFORMANCE LIQUID-CHROMATOGRAPHY ;  ZONE ELECTROPHORESIS ;  AMINO-ACIDS ;  CYCLODEXTRINS ;  DESIGN ;  PHASE ;  ENANTIOMERS ;  RESOLUTION ;  DRUGS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000083356000004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/86221
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Beijing 100864, Peoples R China
2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

Recommended Citation:
Zhu, XF,Lin, BC,Jakob, A,et al. Optimization and parameter study for chiral separation by capillary electrophoresis[J]. HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,1999,22(8):449-453.
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