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Optimization and parameter study for chiral separation by capillary electrophoresis
Zhu, XF; Lin, BC; Jakob, A; Epperlein, U; Koppenhoefer, B
关键词Capillary Electrophoresis Experimental Design Cyclodextrin Chiral Separation
刊名HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY
1999-08-01
22期:8页:449-453
收录类别SCI
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]MICELLAR ELECTROKINETIC CHROMATOGRAPHY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; ZONE ELECTROPHORESIS ; AMINO-ACIDS ; CYCLODEXTRINS ; DESIGN ; PHASE ; ENANTIOMERS ; RESOLUTION ; DRUGS
英文摘要Orthogonal design and uniform design were used for the optimization of separation of enantiomers using 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CD) as a chiral selector by capillary zone electrophoresis, The concentration of DM-beta-CD, buffer pH, running voltage, and capillary temperature were selected as variable parameters, their different effects on peak resolution were studied by the design methods. It was concluded that orthogonal design offers a rapid and efficient means for testing the importance of individual parameters and for determining the optimum operating conditions. However, for a large number of both factors and levels, uniform design is more efficient, The effect of addition of methanol and citric acid buffer on the separation of enantiomers was also examined.
语种英语
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WOS记录号WOS:000083356000004
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/86221
专题中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Beijing 100864, Peoples R China
2.Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany
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GB/T 7714
Zhu, XF,Lin, BC,Jakob, A,et al. Optimization and parameter study for chiral separation by capillary electrophoresis[J]. HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,1999,22(8):449-453.
APA Zhu, XF,Lin, BC,Jakob, A,Epperlein, U,&Koppenhoefer, B.(1999).Optimization and parameter study for chiral separation by capillary electrophoresis.HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY,22(8),449-453.
MLA Zhu, XF,et al."Optimization and parameter study for chiral separation by capillary electrophoresis".HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY 22.8(1999):449-453.
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