中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Application of liquid pre-column capillary electrophoresis technique to the study of interaction between drug enantiomers and human serum albumin
作者: Ding, YS;  Zhu, XF;  Lin, BC
关键词: capillary electrophoresis ;  liquid pre-column ;  binding constant ;  chiral drug ;  human serum albumin
刊名: SCIENCE IN CHINA SERIES B-CHEMISTRY
发表日期: 1999-12-01
卷: 42, 期:6, 页:617-623
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Based on the chiral separation of several basic drugs, dimetindene, tetryzoline, theodrenaline and verapamil, the liquid pre-column capillary electrophoresis (LPC-CE) technique was established. It was used to determine free concentrations of drug enantiomers in mixed solutions with human serum albumin (HSA). To prevent HSA entering the CE chiral separation zone, the mobility differences between HSA and drugs under a specific pH condition were employed in the LPC. Thus, the detection confusion caused by protein was totally avoided. Further study of binding constants determination and protein binding competitions was carried out. The study proves that the LPC technique could be used for complex media, particularly the matrix of protein coexisting with a variety of drugs.
关键词[WOS]: BINDING CONSTANTS ;  PROTEIN-BINDING ;  VANCOMYCIN ;  PEPTIDES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000084653800009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/86229
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
1999LTYND6A882.pdf(469KB)----开放获取--View Download

作者单位: 1.Dalian Maritime Univ, Dalian 116026, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Ding, YS,Zhu, XF,Lin, BC. Application of liquid pre-column capillary electrophoresis technique to the study of interaction between drug enantiomers and human serum albumin[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,1999,42(6):617-623.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Ding, YS]'s Articles
 [Zhu, XF]'s Articles
 [Lin, BC]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Ding, YS]‘s Articles
 [Zhu, XF]‘s Articles
 [Lin, BC]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 1999LTYND6A882.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace