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题名: Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients
作者: Xu, G;  Di Stefano, C;  Liebich, HM;  Zhang, Y;  Lu, P
关键词: pattern recognition ;  nucleosides
刊名: JOURNAL OF CHROMATOGRAPHY B
发表日期: 1999-09-24
卷: 732, 期:2, 页:307-313
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Post-transcriptional modifications in RNA give rise to free modified ribonucleosides circulating in the blood stream and excreted in urine. Due to their abnormal levels in conjunction with several tumor diseases, they have been suggested as possible tumor markers. The developed RP-HPLC method has been applied to analyze the urinary nucleosides in 34 urinary samples from 15 kinds of cancer patients. The statistical analyses showed the urinary nucleoside excretion, especially modified nucleoside levels, in cancer patients were significantly higher than those in normal healthy volunteers. Factor analysis was used to classify the patients with cancer and normal healthy humans. It was found that using 15 urinary nucleoside levels or only five modified nucleoside levels as data vectors the factor analysis plot displayed two almost separate clusters representing each group. (C) 1999 Elsevier Science B.V. All rights reserved.
关键词[WOS]: TUMOR-MARKER ;  CAPILLARY ELECTROPHORESIS ;  RNA TURNOVER ;  EXCRETION ;  PSEUDOURIDINE ;  QUANTITATION ;  CARCINOMA ;  LEUKEMIA ;  LUNG
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000082839700006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/86241
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Univ Tubingen, Med Klin, D-72076 Tubingen, Germany

Recommended Citation:
Xu, G,Di Stefano, C,Liebich, HM,et al. Reversed-phase high-performance liquid chromatographic investigation of urinary normal and modified nucleosides of cancer patients[J]. JOURNAL OF CHROMATOGRAPHY B,1999,732(2):307-313.
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