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题名: Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue
作者: Eckel, R;  Huo, H;  Guan, HW;  Hu, X;  Che, X;  Huang, WD
关键词: Fourier transform infrared spectroscopy ;  protein bands ;  normal, benign and malignant human breast tissues
刊名: VIBRATIONAL SPECTROSCOPY
发表日期: 2001-12-07
卷: 27, 期:2, 页:165-173
收录类别: SCI
文章类型: Article
部门归属: 1023
项目归属: 103
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Analytical ;  Chemistry, Physical ;  Spectroscopy
研究领域[WOS]: Chemistry ;  Spectroscopy
英文摘要: Infrared (IR) spectra of normal, hyperplasia, fibroadenoma and carcinoma tissues of human breast obtained from 96 patients have been determined and analyzed statistically. Several spectral differences were detected in the frequency regions of N-H stretching, amide I, II and III bands: (1) the bands in the region 3000-3600cm-1 shifted to lower frequencies for the carcinomatous tissue; (2) the A(3300)/A(3075) absorbance ratio was significantly higher for the fibroadenoma than for the other types of tissues; (3) the frequency of the a-helix amide I band decreased for the malignant tissue, while the corresponding beta -sheet amide I band frequency increased; (4) the A(1657)/A(1635) and A(1553)/A(1540) absorbance ratios were the highest for fibroadenoma and carcinoma tissues; (5) the A(1680)/A(1657) absorbance ratio decreased significantly in the order of normal > hyperplasia > fibroadenoma > carcinoma; (6) the A(1651)/A(1545) absorbance ratio increased slightly for the fibroadenoma and the carcinoma tissues; (7) the bands at 1204 and 1278 cm(-1), assigned to the vibrational modes of the collagen, did not appear in the original spectra as resolved peaks and were distinctly stronger in the deconvoluted spectra of the carcinoma tissue and (8) the A(1657)/A(1204) and A(1657)/A(1278) absorbance ratios, both yielding information on the relative content of collagen, increased in the order of normal < hyperplasia < carcinoma < fibroadenoma. The said differences imply that the information is useful for the diagnosis of breast cancer and malignant breast abnormalities, and may serve as a basis for further studies on conformational changes in tissue proteins during carcinogenesis. (C) 2001 Elsevier Science B.V. All rights reserved.
关键词[WOS]: TUNING FT-IR ;  SPECTRA ;  SPECTROMETRY ;  CELLS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000172407400009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/91893
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116012, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dalian 116011, Peoples R China

Recommended Citation:
Eckel, R,Huo, H,Guan, HW,et al. Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue[J]. VIBRATIONAL SPECTROSCOPY,2001,27(2):165-173.
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