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题名: Characteristics of elution profile in radial chromatography under linear conditions
作者: Zhang, WB;  Shan, YC;  Seidel-Morgenstern, A;  Zhang, YK
通讯作者: 张维冰
关键词: radial chromatography ;  column efficiency ;  elution profile ;  symmetry
刊名: SCIENCE IN CHINA SERIES B-CHEMISTRY
发表日期: 2005-08-01
DOI: 10.1360/042004-50
卷: 48, 期:4, 页:352-360
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要: Based on the mass balance equations of solute transfer in the radial chromatographic column, the theoretical expression to describe the column efficiency and shape of elution profile is obtained under linear isotherm case. Moreover, the tendency for the variation of column efficiency and symmetry of peak profile is systematically discussed. The results showed that in radial chromatography the relationship between the column efficiency and volumetric flow rate is similar with that relationship in axial chromatography; relatively high column efficiency still can be obtained under high flow rate in radial chromatography. Accompanying the increase of retention factor of solutes and injection time, the column efficiency decreases monotonously. The effect of column diameter and column length on the column efficiency interfere with each other. It is more advantageous to increase the column efficiency by applying columns with larger column diameter and shorter column length. According to the discussion of the effect of diffusion on the column efficiency, radial chromatography is proved to be suitable for the separation of samples with relatively high diffusion coefficient, which predicts its obvious advantage in the preparative separation of samples such as proteins and DNA.
关键词[WOS]: FLOW CHROMATOGRAPHY ;  AFFINITY-CHROMATOGRAPHY ;  ION-EXCHANGE ;  PLATE-THEORY ;  BEDS ;  PURIFICATION ;  DYNAMICS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000232174700011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/92471
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Max Planck Inst Dynam Komplexer Tech Syst, D-39106 Magdeburg, Germany

Recommended Citation:
Zhang, WB,Shan, YC,Seidel-Morgenstern, A,et al. Characteristics of elution profile in radial chromatography under linear conditions[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2005,48(4):352-360.
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