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Characteristics of elution profile in radial chromatography under linear conditions
Zhang, WB; Shan, YC; Seidel-Morgenstern, A; Zhang, YK; Zhang WB(张维冰); Zhang WB(张维冰)
关键词Radial Chromatography Column Efficiency Elution Profile Symmetry
刊名SCIENCE IN CHINA SERIES B-CHEMISTRY
2005-08-01
DOI10.1360/042004-50
48期:4页:352-360
收录类别SCI
文章类型Article
部门归属18
项目归属1810
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]FLOW CHROMATOGRAPHY ; AFFINITY-CHROMATOGRAPHY ; ION-EXCHANGE ; PLATE-THEORY ; BEDS ; PURIFICATION ; DYNAMICS
英文摘要Based on the mass balance equations of solute transfer in the radial chromatographic column, the theoretical expression to describe the column efficiency and shape of elution profile is obtained under linear isotherm case. Moreover, the tendency for the variation of column efficiency and symmetry of peak profile is systematically discussed. The results showed that in radial chromatography the relationship between the column efficiency and volumetric flow rate is similar with that relationship in axial chromatography; relatively high column efficiency still can be obtained under high flow rate in radial chromatography. Accompanying the increase of retention factor of solutes and injection time, the column efficiency decreases monotonously. The effect of column diameter and column length on the column efficiency interfere with each other. It is more advantageous to increase the column efficiency by applying columns with larger column diameter and shorter column length. According to the discussion of the effect of diffusion on the column efficiency, radial chromatography is proved to be suitable for the separation of samples with relatively high diffusion coefficient, which predicts its obvious advantage in the preparative separation of samples such as proteins and DNA.
语种英语
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WOS记录号WOS:000232174700011
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/92471
专题中国科学院大连化学物理研究所
通讯作者Zhang WB(张维冰); Zhang WB(张维冰)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Max Planck Inst Dynam Komplexer Tech Syst, D-39106 Magdeburg, Germany
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Zhang, WB,Shan, YC,Seidel-Morgenstern, A,et al. Characteristics of elution profile in radial chromatography under linear conditions[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2005,48(4):352-360.
APA Zhang, WB,Shan, YC,Seidel-Morgenstern, A,Zhang, YK,张维冰,&张维冰.(2005).Characteristics of elution profile in radial chromatography under linear conditions.SCIENCE IN CHINA SERIES B-CHEMISTRY,48(4),352-360.
MLA Zhang, WB,et al."Characteristics of elution profile in radial chromatography under linear conditions".SCIENCE IN CHINA SERIES B-CHEMISTRY 48.4(2005):352-360.
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