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Characteristics of elution profile in radial chromatography under linear conditions
Zhang, WB; Shan, YC; Seidel-Morgenstern, A; Zhang, YK; Zhang WB(张维冰); Zhang WB(张维冰)
KeywordRadial Chromatography Column Efficiency Elution Profile Symmetry
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
2005-08-01
DOI10.1360/042004-50
Volume48Issue:4Pages:352-360
Indexed BySCI
SubtypeArticle
Department18
Funding Project1810
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordFLOW CHROMATOGRAPHY ; AFFINITY-CHROMATOGRAPHY ; ION-EXCHANGE ; PLATE-THEORY ; BEDS ; PURIFICATION ; DYNAMICS
AbstractBased on the mass balance equations of solute transfer in the radial chromatographic column, the theoretical expression to describe the column efficiency and shape of elution profile is obtained under linear isotherm case. Moreover, the tendency for the variation of column efficiency and symmetry of peak profile is systematically discussed. The results showed that in radial chromatography the relationship between the column efficiency and volumetric flow rate is similar with that relationship in axial chromatography; relatively high column efficiency still can be obtained under high flow rate in radial chromatography. Accompanying the increase of retention factor of solutes and injection time, the column efficiency decreases monotonously. The effect of column diameter and column length on the column efficiency interfere with each other. It is more advantageous to increase the column efficiency by applying columns with larger column diameter and shorter column length. According to the discussion of the effect of diffusion on the column efficiency, radial chromatography is proved to be suitable for the separation of samples with relatively high diffusion coefficient, which predicts its obvious advantage in the preparative separation of samples such as proteins and DNA.
Language英语
URL查看原文
WOS IDWOS:000232174700011
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/92471
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang WB(张维冰); Zhang WB(张维冰)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Max Planck Inst Dynam Komplexer Tech Syst, D-39106 Magdeburg, Germany
Recommended Citation
GB/T 7714
Zhang, WB,Shan, YC,Seidel-Morgenstern, A,et al. Characteristics of elution profile in radial chromatography under linear conditions[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2005,48(4):352-360.
APA Zhang, WB,Shan, YC,Seidel-Morgenstern, A,Zhang, YK,张维冰,&张维冰.(2005).Characteristics of elution profile in radial chromatography under linear conditions.SCIENCE IN CHINA SERIES B-CHEMISTRY,48(4),352-360.
MLA Zhang, WB,et al."Characteristics of elution profile in radial chromatography under linear conditions".SCIENCE IN CHINA SERIES B-CHEMISTRY 48.4(2005):352-360.
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