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Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography
Zhang, Y; Chen, JP; Zhang, CZ; Wu, WZ; Liang, XM; Liang XM(梁鑫淼); Liang XM(梁鑫淼)
关键词Phytoestrogens Kudzu Root Recombinant Yeast Hplc
刊名JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
2005-03-01
DOI10.1016/j.jsbmb.2004.10.022
94期:4页:375-381
收录类别SCI
文章类型Article
部门归属1,18
项目归属103,1803
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]HORMONE REPLACEMENT THERAPY ; LARGE-SCALE USE ; ISOFLAVONES ; FLAVONOIDS ; PUERARIAE ; GENISTEIN ; DAIDZEIN ; EXTRACTS ; RADIX ; RISK
英文摘要The estrogenic activity of the Chinese herb kudzu root was investigated by a recombinant yeast screening assay (YES). Isoflavones are the main components in the plant, of which puerarin is the most abundant one. The kudzu root extract was separated into four fractions according to the polarity. The crude extract and its sub-fractions, except the water fraction, showed clear estrogenic activity and the potencies were in the range of 10(-3) to 10(-1) g/l. The ligand potency was used to compare the estrogenic activity of these fractions. The crude extract and its sub-fractions were further analyzed by high performance liquid chromatography (HPLC) to correlate the activity and the active components. Bioassay and chemical analysis showed that theoretical estrogenic activity expressed as equivalent 17 beta-estradiol concentration or the cumulative effects are comparable to that experimentally determined by YES. The results showed that the high content of isoflavones as well as the high estrogenic activity could make kudzu root extract an interesting candidate for hormone replacement therapy. (c) 2005 Elsevier Ltd. All rights reserved.
语种英语
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WOS记录号WOS:000229445800011
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/92509
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼); Liang XM(梁鑫淼)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
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GB/T 7714
Zhang, Y,Chen, JP,Zhang, CZ,et al. Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography[J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,2005,94(4):375-381.
APA Zhang, Y.,Chen, JP.,Zhang, CZ.,Wu, WZ.,Liang, XM.,...&梁鑫淼.(2005).Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography.JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,94(4),375-381.
MLA Zhang, Y,et al."Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography".JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 94.4(2005):375-381.
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