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题名: Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS
作者: Pan, CS;  Xu, SY;  Hu, LG;  Su, XY;  Ou, JJ;  Zou, HF;  Guo, Z;  Zhang, Y;  Guo, BC
通讯作者: 邹汉法
刊名: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
发表日期: 2005-06-01
DOI: 10.1016/j.jasms.2005.03.009
卷: 16, 期:6, 页:883-892
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences ;  Technology
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical ;  Chemistry, Physical ;  Spectroscopy
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Spectroscopy
英文摘要: Oxidized carbon nanotubes are tested as a matrix for analysis of small molecules by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS). Compared with nonoxidized carbon nanotubes, oxidized carbon nanotubes facilitate sample preparation because of their higher solubility in water. The matrix layer of oxidized carbon nanotubes is much more homogeneous and compact than that of nonoxidized carbon nanotubes. The efficiency of desorption/ionization for analytes and the reproducibility of peak intensities within and between sample spots are greatly enhanced on the surface of oxidized carbon nanotubes. The advantage of the oxidized carbon nanotubes in comparison with alpha-cyano-4-hydroxycinnamic acid (CCA) and carbon nanotubes is demonstrated by MALDI-TOF-MS analysis of an amino acid mixture. The matrix is successfully used for analysis of synthetic hydroxypropyl P-cyclodextrin, suggesting a great potential for monitoring reactions and for product quality control. Reliable quantitative analysis of jatrorrhizine and palmatine with a wide linear range (1-100 ng/mL) and good reproducibility of relative peak areas (RSD less than 10 %) is achieved using this matrix. Concentrations of jatrorrhizine (8.65 mg/mL) and palmatine (10.4 mg/mL) in an extract of Coptis chinensis Franch are determined simultaneously using the matrix and a standard addition method. (c) 2005 American Society for Mass Spectrometry.
关键词[WOS]: ASSISTED-LASER-DESORPTION/IONIZATION ;  FLIGHT MASS-SPECTROMETRY ;  POST-SOURCE DECAY ;  QUANTITATIVE-ANALYSIS ;  ACTIVATED CARBON ;  POROUS SILICON ;  SURFACE ;  PEPTIDES ;  PROTEINS ;  PSD
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000229244800009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/92737
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Res Ctr EcoEnvironm Sci, Beijing, Peoples R China
3.Cleveland State Univ, Dept Chem, Cleveland, OH 44115 USA

Recommended Citation:
Pan, CS,Xu, SY,Hu, LG,et al. Using oxidized carbon nanotubes as matrix for analysis of small molecules by MALDI-TOF MS[J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,2005,16(6):883-892.
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