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题名: Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals
作者: Xie, CH;  Hu, JW;  Xiao, H;  Su, XY;  Dong, J;  Tian, RJ;  He, ZK;  Zou, HF
通讯作者: 邹汉法
关键词: basic pharmaceutical ;  electrochromatography ;  retention mechanism ;  silica monolith
刊名: ELECTROPHORESIS
发表日期: 2005-02-01
DOI: 10.1002/elps.200410174
卷: 26, 期:4-5, 页:790-797
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: A silica-based monolithic capillary column was prepared via a sol-gel process. The continuous skeleton and large through-pore structure were characterized by scanning electron microscopy (SEM). The native silica monolith has been successfully employed in the electrochromatographic separation of beta-blockers and alkaloids extracted from traditional Chinese medicines (TCMs). Column efficiencies greater than 250000 plates/m for capillary electrochromatography (CEC) separation of basic compounds were obtained. It was observed that retention of basic pharmaceuticals on the silica monolith was mainly contributed by a cation-exchange mechanism. Other retention mechanisms including reversed-phase and normal-phase mechanisms and electrophoresis of basic compounds also played a role in separation. A comparison of the differences between CEC and capillary zone electrophoresis (CZE) separation was also discussed.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  AQUEOUS METHANOL ELUENT ;  REVERSED-PHASE ;  STATIONARY-PHASE ;  DRUGS ;  ACID ;  GEL ;  ENANTIOSEPARATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000227425400007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/92743
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

Recommended Citation:
Xie, CH,Hu, JW,Xiao, H,et al. Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals[J]. ELECTROPHORESIS,2005,26(4-5):790-797.
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