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题名: A new cellular model for in vitro biocompatibility evaluation of microcapsule materials
作者: Zhang, H;  Sun, L;  Wang, W;  Ma, XJ;  Zhang, X;  Tanaka, J;  Yu, Y;  Tabata, Y
通讯作者: 马小军
关键词: biocompatibility ;  in-vitro ;  alginate ;  chitosan
刊名: ASBM6: ADVANCED BIOMATERIALS VI
发表日期: 2005
卷: 288-289, 页:499-502
收录类别: ISTP ;  SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical ;  Materials Science, Ceramics ;  Materials Science, Biomaterials ;  Materials Science, Composites
研究领域[WOS]: Engineering ;  Materials Science
英文摘要: Fibrosis caused by the host response to long-term transplanted microcapsules and the limitation of traditional L929 cell model for biocompatibility testing inspire the development of an assay of biocompatibility based on macrophage behavior. In this paper, the human monocytic cell line THP-1 was utilized for biocompatibility evaluation of microcapsule materials. The cell viability and secretion of nitric oxide (NO) and cytokines served as index of biocompatibility were assayed. It was found that the evaluated microcapsule materials had no effect on the stimulation of NO and cytokines secretion, which meant that these materials were biocompatible. Furthermore, it suggests the THP-1 cell a convenient in vitro experimental model that might be useful for long-term predictions of material biocompatibility.
关键词[WOS]: ISLETS ;  THP-1
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000230426600122
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/92781
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Grad Sch, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian, Peoples R China

Recommended Citation:
Zhang, H,Sun, L,Wang, W,et al. A new cellular model for in vitro biocompatibility evaluation of microcapsule materials[J]. ASBM6: ADVANCED BIOMATERIALS VI,2005,288-289:499-502.
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