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题名: Low temperature heat capacity of (S)-ibuprofen
作者: Xu, F;  Sun, LX;  Tan, ZC;  Li, RL;  Tian, QF;  Zhang, T
通讯作者: 孙立贤
关键词: (S)-ibuprofen ;  adiabatic calorimetry ;  heat capacity
刊名: ACTA PHYSICO-CHIMICA SINICA
发表日期: 2005
DOI: 10.3866/PKU.WHXB20050101
卷: 21, 期:1, 页:1-5
收录类别: SCI
文章类型: Article
部门归属: 15
项目归属: 1504
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: Molar heat capacities of ( S)-ibuprofen were precisely measured with a small sample precision automated adiabatic calorimeter over the temperature range from 80 to 370 K. Experimental heat capacities were fitted into a polynomial equation of heat capacities ( C-p,C- m) with reduced temperature ( X), [ X = f(T)]. The polynomial equations for ( S)-ibuprofen were C-p,C- m(s) = - 39.483 X-4 - 66. 649 X-3 + 95. 196 X-2 + 210. 84 X + 172. 98 in solid state and C-p,C- m(L) = 7. 191X(3) + 4. 2774 X-2 + 56. 365 X + 498. 5 in liquid state. The thermodynamic functions relative to the reference temperature of 298. 15 K, H-T - H-298.15 and S-T - S-298.15, were derived for the( S)-ibuprofen. A fusion transition at T-m = (324. 15 +/- 0. 02) K was found from the C-p - T curve. The molar enthalpy and entropy of the fusion transition were determined to be (18. 05 +/- 0. 31) kJ.mol(-1) and (55. 71 +/- 0. 95) J.mol(-1).K-1, respectively. The purity of the ( S)-ibuprofen was determined to be 99. 44% on the basis of the heat capacity measurement. Finally, the heat capacities of ( S)-ibuprofen and racemic ibuprofen were compared.
关键词[WOS]: IBUPROFEN ;  CALORIMETRY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000226537000001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/92821
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
2.Hunan Inst Drug Detect, Changsha 410001, Peoples R China

Recommended Citation:
Xu, F,Sun, LX,Tan, ZC,et al. Low temperature heat capacity of (S)-ibuprofen[J]. ACTA PHYSICO-CHIMICA SINICA,2005,21(1):1-5.
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