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题名: Age-dependence of urinary normal and modified nucleosides in childhood as determined by reversed-phase high-performance liquid chromatography
作者: Liebich, HM;  Muller-Hagedorn, S;  Bacher, M;  Scheel-Walter, HG;  Lu, X;  Frickenschmidt, A;  Kammerer, B;  Kim, KR;  Gerard, H
通讯作者: H.M. Liebich
关键词: nucleosides ;  age dependence
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2005-01-25
DOI: 10.1016/j.jchromb.2004.10.051
卷: 814, 期:2, 页:275-283
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 4;5
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Modified nucleosides have been characterized as tumor markers for a number of malignant diseases. In order to use these markers in children, the age-dependence of the nucleoside levels in healthy children has to be established and taken into account in diagnostic decisions. In this study, the levels of 12 normal and modified nucleosides in urine of 166 healthy children and adolescents with an age between 1 day and 19 years are determined by reversed-phase HPLC, and age-dependent reference ranges are defined. The urinary nucleoside concentrations are related to the creatinine concentrations, which allows the use of randomly collected urine samples. All nucleoside levels in urine of children decrease with age, most pronounced during the first 4 years of life, and the age-dependence of the reference values of the individual nucleosides can be approximated by a mathematical function y = b(0) + b(1) (1/x) with the regression coefficients b(0) and b(1), the nucleoside levels y and the age x between 1 year and 19 years. In the very young children, the shifts in the nucleoside concentrations are more differentiated. Starting with low levels on the first day of life, the concentrations of all studied nucleosides rise up to an age of 1-2 months, when they reach their absolute maximum for all age periods, and then decrease. (C) 2004 Elsevier B.V. All rights reserved.
关键词[WOS]: RNA TURNOVER ;  EXCRETION ;  PROTEIN ;  CANCER ;  MARKER ;  PSEUDOURIDINE ;  CATABOLITES ;  METABOLISM ;  CARCINOMA ;  PATTERNS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000226438400010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/92875
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, Med Klin, Abt 4, Zentrallab, D-72076 Tubingen, Germany
2.Zentrum Zahn Mund & Kieferheilkunde, Poliklin Kieferorthopadie, D-72076 Tubingen, Germany
3.Univ Tubingen, Kinderklin, D-72076 Tubingen, Germany
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
5.Univ Tubingen, Klin Pharmakol Abt, D-72076 Tubingen, Germany
6.Sungkyunkwan Univ, Coll Pharm, Suwon 440746, South Korea
7.CHRU, Lab Biol Reprod & Dev, F-52042 Nancy, France

Recommended Citation:
Liebich, HM,Muller-Hagedorn, S,Bacher, M,et al. Age-dependence of urinary normal and modified nucleosides in childhood as determined by reversed-phase high-performance liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2005,814(2):275-283.
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