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题名: Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts
作者: Li, QR;  Tan, L;  Wang, C;  Li, N;  Li, YS;  Xu, GW;  Li, JS
通讯作者: 黎介寿
关键词: polyunsaturated fatty acids ;  eicosapentaenoic acid ;  lipid rafts ;  lipid composition
刊名: EUROPEAN JOURNAL OF NUTRITION
发表日期: 2006-04-01
DOI: 10.1007/s00394-005-0574-7
卷: 45, 期:3, 页:144-151
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2;3
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
英文摘要: Background Polyunsaturated fatty acids (PUFAs) modulate immune responses particularly by affecting T cell function and are applied clinically as adjuvant immunosuppressants in the treatment of various inflammatory diseases. However, the molecular mechanisms of PUFA-induced immunosuppressive effects are not yet elucidated. Membrane lipid rafts are functional plasma membrane microdomains characterized by a unique lipid environment. Since lipid interactions are crucial for the formation of lipid rafts, the immunomodulatory effects of PUFAs may be due to changes of fatty acid composition in lipid rafts.
关键词[WOS]: FATTY-ACIDS ;  MEMBRANE ;  INHIBITION ;  ACTIVATION ;  DOMAINS ;  DISEASE ;  CELLS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000236201500003
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/92881
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Peoples R China

Recommended Citation:
Li, QR,Tan, L,Wang, C,et al. Polyunsaturated eicosapentaenoic acid changes lipid composition in lipid rafts[J]. EUROPEAN JOURNAL OF NUTRITION,2006,45(3):144-151.
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