DICP OpenIR
Resolution prediction and optimization of temperature programme in comprehensive two-dimensional gas chromatography
Lu, X; Kong, HW; Li, HF; Ma, CF; Tian, J; Xu, GW; Xu GW(许国旺); Xu GW(许国旺)
KeywordComprehensive Two-dimensional Gas Chromatography Resolution Prediction Optimization Temperature Program
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2005-09-09
DOI10.1016/j.chroma.2005.05.105
Volume1086Issue:1-2Pages:175-184
Indexed ByISTP ; SCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordFLIGHT MASS-SPECTROMETRY ; ISOTHERMAL DATA ; RETENTION INDEXES ; CIGARETTE-SMOKE ; PEAK WIDTH ; TIME
AbstractA model is developed for predicting the resolution of interested component pair and calculating the optimum temperature programming condition in the comprehensive two-dimensional gas chromatography (GC x GC). Based on at least three isothermal runs, retention times and the peak widths at half-height on both dimensions are predicted for any kind of linear temperature-programmed run on the first dimension and isothermal runs on the second dimension. The calculation of the optimum temperature programming condition is based on the prediction of the resolution of "difficult-to-separate components" in a given mixture. The resolution of all the neighboring peaks on the first dimension is obtained by the predicted retention time and peak width on the first dimension, the resolution on the second dimension is calculated only for the adjacent components with un-enough resolution on the first dimension and eluted within a same modulation period on the second dimension. The optimum temperature programming condition is acquired when the resolutions of all components of interest by GC x GC separation meet the analytical requirement and the analysis time is the shortest. The validity of the model has been proven by using it to predict and optimize GC x GC temperature programming condition of an alkylpyridine mixture. (c) 2005 Elsevier B.V. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000231185500022
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/92883
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺); Xu GW(许国旺)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Lu, X,Kong, HW,Li, HF,et al. Resolution prediction and optimization of temperature programme in comprehensive two-dimensional gas chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2005,1086(1-2):175-184.
APA Lu, X.,Kong, HW.,Li, HF.,Ma, CF.,Tian, J.,...&许国旺.(2005).Resolution prediction and optimization of temperature programme in comprehensive two-dimensional gas chromatography.JOURNAL OF CHROMATOGRAPHY A,1086(1-2),175-184.
MLA Lu, X,et al."Resolution prediction and optimization of temperature programme in comprehensive two-dimensional gas chromatography".JOURNAL OF CHROMATOGRAPHY A 1086.1-2(2005):175-184.
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