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题名: Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography
作者: Sheng, LH;  Li, SL;  Kong, L;  Chen, XG;  Mao, XQ;  Su, XY;  Zou, HF;  Li, P
通讯作者: 邹汉法 ;  李萍
关键词: immobilized liposome chromatography ;  compounds interacting with liposome membranes ;  Danggui Buxue decoction ;  Radix Astragli ;  Radix Angelica Sinensis
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2005-06-15
DOI: 10.1016/j.jpba.2005.01.008
卷: 38, 期:2, 页:216-224
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: Immobilized liposome chromatography (ILC), the stationary phase of which has been regarded as a mimic biomembranes system was used to separate and analyze compounds interacting with liposome membrane in Danggui Buxue decoction, a combined prescription of traditional Chinese medicines (CPTCMs), and its compositions Radix Astragli and Radix Angelica Sinensis. More than 10 main peaks in the extract of Danggui Buxue decoction were resolved on the ILC column, suggesting that more than 10 components in the prescription have significant retention on ILC column. Ligustilide, astragaloside, TV and formononetin, three main bioactive ingredients in Danggui Buxue decoction, were found to have relatively significant, while ferulic acid, another bioactive ingredient in the prescription, relatively weak retention on ILC column. Effects of the eluent pH and amount of immobilized phosphatidylcholine (PC) on separation of interactional compounds in the extract of Danggui Buxue decoction were also investigated. It was found that these two factors strongly affected the retention of some interactional compounds. In addition, the fractions partitioned with different solvents from water extract of this combined prescription were evaluated with this ILC column system. (c) 2005 Elsevier B.V. All rights reserved.
关键词[WOS]: LIQUID-CHROMATOGRAPHY ;  ANGELICA-SINENSIS ;  BIOMEMBRANE CHROMATOGRAPHY ;  UNILAMELLAR LIPOSOMES ;  MASS-SPECTROMETRY ;  HERBAL MEDICINES ;  DRUGS ;  PERMEABILITY ;  LIGUSTILIDE ;  MODEL
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000230217600004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/93377
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.China Pharmaceut Univ, Key Lab Modern Chinese Med, Nanjing 210009, Peoples R China
3.China Pharmaceut Univ, Dept Pharmacognosy, Nanjing 210009, Peoples R China

Recommended Citation:
Sheng, LH,Li, SL,Kong, L,et al. Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2005,38(2):216-224.
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