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Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC
Guo, M; Su, XY; Kong, L; Li, X; Zou, HF; Zou HF(邹汉法); Zou HF(邹汉法)
关键词Interaction Traditional Chinese Medicine Protein Microdialysis Hplc
刊名ANALYTICA CHIMICA ACTA
2006-01-18
ISSN0003-2670
DOI10.1016/j.aca.2005.07.064
556期:1页:183-188
收录类别SCI
文章类型Article
部门归属18
项目归属1809
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN SERUM-ALBUMIN ; METAL-IONS ; BINDING ; CHUANXIONG ; IDENTIFICATION ; SEPARATION ; DELIVERY ; DRUGS ; MS
英文摘要Interaction of traditional Chinese Herb Rhizoma Chuanxiong and protein was studied by microdialysis coupled with high performance liquid chromatography. Compounds in Rhizoma Chuanxiong, such as ferulic acid, senkyunolide A and 3-butylphthalide, were identified by HPLC, HPLC-MS and UV-vis. Microdialysis recoveries and binding degrees of compounds in Rhizoma Chuanxiong with human serum albumin (HSA) and other human plasma protein were determined: recoveries of microdialysis sampling ranged from 36.7 to 98.4% with R.S.D. below 3.1%; while binding to HSA ranged from 0 to 91.5% (0.3 mM HSA) and from 0 to 93.5% (0.6 mM HSA), respectively. Compared with HSA, most of compounds bound to human blood serum more extensively and the results showed that binding of these compounds in Rhizoma Chuanxiong was influenced by pH. Two compounds were found to bind to HSA and human blood serum. their binding degrees were consistent with ferulic acid and 3-butylphthalide, the active compounds in Rhizoma Chuanoxiong. (c) 2005 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000234724900023
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被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/93381
专题中国科学院大连化学物理研究所
通讯作者Zou HF(邹汉法); Zou HF(邹汉法)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Dalian Univ Econ & Technol Dev Dist, Dept Chem & Chem Technol, Dalian 116622, Peoples R China
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Guo, M,Su, XY,Kong, L,et al. Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC[J]. ANALYTICA CHIMICA ACTA,2006,556(1):183-188.
APA Guo, M.,Su, XY.,Kong, L.,Li, X.,Zou, HF.,...&邹汉法.(2006).Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC.ANALYTICA CHIMICA ACTA,556(1),183-188.
MLA Guo, M,et al."Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC".ANALYTICA CHIMICA ACTA 556.1(2006):183-188.
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