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题名: Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC
作者: Guo, M;  Su, XY;  Kong, L;  Li, X;  Zou, HF
通讯作者: 邹汉法
关键词: interaction ;  traditional Chinese medicine ;  protein ;  microdialysis ;  HPLC
刊名: ANALYTICA CHIMICA ACTA
发表日期: 2006-01-18
DOI: 10.1016/j.aca.2005.07.064
卷: 556, 期:1, 页:183-188
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Interaction of traditional Chinese Herb Rhizoma Chuanxiong and protein was studied by microdialysis coupled with high performance liquid chromatography. Compounds in Rhizoma Chuanxiong, such as ferulic acid, senkyunolide A and 3-butylphthalide, were identified by HPLC, HPLC-MS and UV-vis. Microdialysis recoveries and binding degrees of compounds in Rhizoma Chuanxiong with human serum albumin (HSA) and other human plasma protein were determined: recoveries of microdialysis sampling ranged from 36.7 to 98.4% with R.S.D. below 3.1%; while binding to HSA ranged from 0 to 91.5% (0.3 mM HSA) and from 0 to 93.5% (0.6 mM HSA), respectively. Compared with HSA, most of compounds bound to human blood serum more extensively and the results showed that binding of these compounds in Rhizoma Chuanxiong was influenced by pH. Two compounds were found to bind to HSA and human blood serum. their binding degrees were consistent with ferulic acid and 3-butylphthalide, the active compounds in Rhizoma Chuanoxiong. (c) 2005 Elsevier B.V. All rights reserved.
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ;  HUMAN SERUM-ALBUMIN ;  METAL-IONS ;  BINDING ;  CHUANXIONG ;  IDENTIFICATION ;  SEPARATION ;  DELIVERY ;  DRUGS ;  MS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000234724900023
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/93381
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116011, Peoples R China
2.Dalian Univ Econ & Technol Dev Dist, Dept Chem & Chem Technol, Dalian 116622, Peoples R China

Recommended Citation:
Guo, M,Su, XY,Kong, L,et al. Characterization of interaction property of multicomponents in Chinese Herb with protein by microdialysis combined with HPLC[J]. ANALYTICA CHIMICA ACTA,2006,556(1):183-188.
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