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Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi
Han, QB; Wang, YL; Yang, L; Tso, TF; Qiao, CF; Song, JZ; Xu, LJ; Chen, SL; Yang, DJ; Xu, HX; Hong-Xi XU; Hong-Xi XU
关键词Garcinia Hanburyi Cytotoxicity Xanthone Multidrug Resistance Gaudichaudic Acid Isogambogenic Acid
刊名CHEMICAL & PHARMACEUTICAL BULLETIN
2006-02-01
54期:2页:265-267
收录类别SCI ; IC
文章类型Article
部门归属18
项目归属1806
产权排名2;2
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]GAMBOGIC ACID ; IN-VITRO ; CELLS ; PROLIFERATION ; APOPTOSIS ; ASSAY
英文摘要Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.
语种英语
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WOS记录号WOS:000235852700027
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被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/93685
专题中国科学院大连化学物理研究所
通讯作者Hong-Xi XU; Hong-Xi XU
作者单位1.Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resources Discovery, Dalian 116023, Peoples R China
3.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
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GB/T 7714
Han, QB,Wang, YL,Yang, L,et al. Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2006,54(2):265-267.
APA Han, QB.,Wang, YL.,Yang, L.,Tso, TF.,Qiao, CF.,...&Hong-Xi XU.(2006).Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi.CHEMICAL & PHARMACEUTICAL BULLETIN,54(2),265-267.
MLA Han, QB,et al."Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi".CHEMICAL & PHARMACEUTICAL BULLETIN 54.2(2006):265-267.
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