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题名: Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi
作者: Han, QB;  Wang, YL;  Yang, L;  Tso, TF;  Qiao, CF;  Song, JZ;  Xu, LJ;  Chen, SL;  Yang, DJ;  Xu, HX
通讯作者: Hong-Xi XU
关键词: Garcinia hanburyi ;  cytotoxicity ;  xanthone ;  multidrug resistance ;  gaudichaudic acid ;  isogambogenic acid
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2006-02-01
卷: 54, 期:2, 页:265-267
收录类别: SCI ;  IC
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 2;2
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Chemistry, Medicinal ;  Chemistry, Multidisciplinary ;  Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy ;  Chemistry
英文摘要: Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.
关键词[WOS]: GAMBOGIC ACID ;  IN-VITRO ;  CELLS ;  PROLIFERATION ;  APOPTOSIS ;  ASSAY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000235852700027
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/93685
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resources Discovery, Dalian 116023, Peoples R China
3.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

Recommended Citation:
Han, QB,Wang, YL,Yang, L,et al. Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2006,54(2):265-267.
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