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Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa
Wang, HD; Tan, CY; Bai, XF; Du, YG; Lin, BC; Wang HD(王焕弟)
KeywordGentianopsis Paludosa Anti-diarrhoeal Isolated Ileum
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
2006-04-21
DOI10.1016/j.jep.2005.10.002
Volume105Issue:1-2Pages:114-117
Indexed BySCI
SubtypeArticle
Department18
Funding Project1805
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS KeywordEXTRACT ; ILEUM ; RATS
AbstractThe pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa were carried out. The 75% ethanol extract (100-400 mg/kg) of Gentianopsis paludosa inhibited castor oil-induced diarrhoea and also reduced gastrointestinal motility in the charcoal meal test in mice. In the rabbit-isolated ileum, the extract showed inhibitory effects not only on its spontaneous contraction, but also on acetylcholine (Ach, 0.1 mM)- and KCl (60 mM)-induced contractions. Furthermore, the ethanol extract (0.4-0.6 mg/ml) shifted the CaCl2 dose-effect curves to the right in a non-competitive manner and significantly reduced the acetylcholine-induced contraction of isolated ileum in Ca2+-free solution like verapamil (0.1 mM), which suggest that the extract interferes with Ca2+ movement. These results support the traditional use of Gentianopsis paludosa in the treatment of diarrhoea. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000237101300016
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/93693
Collection中国科学院大连化学物理研究所
Corresponding AuthorWang HD(王焕弟)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Nat Prod & Glycoconjugate Res Grp 1805, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Microfluid Syst Biol, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Wang, HD,Tan, CY,Bai, XF,et al. Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):114-117.
APA Wang, HD,Tan, CY,Bai, XF,Du, YG,Lin, BC,&王焕弟.(2006).Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa.JOURNAL OF ETHNOPHARMACOLOGY,105(1-2),114-117.
MLA Wang, HD,et al."Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa".JOURNAL OF ETHNOPHARMACOLOGY 105.1-2(2006):114-117.
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