DICP OpenIR
Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa
Wang, HD; Tan, CY; Bai, XF; Du, YG; Lin, BC; Wang HD(王焕弟)
关键词Gentianopsis Paludosa Anti-diarrhoeal Isolated Ileum
刊名JOURNAL OF ETHNOPHARMACOLOGY
2006-04-21
DOI10.1016/j.jep.2005.10.002
105期:1-2页:114-117
收录类别SCI
文章类型Article
部门归属18
项目归属1805
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]EXTRACT ; ILEUM ; RATS
英文摘要The pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa were carried out. The 75% ethanol extract (100-400 mg/kg) of Gentianopsis paludosa inhibited castor oil-induced diarrhoea and also reduced gastrointestinal motility in the charcoal meal test in mice. In the rabbit-isolated ileum, the extract showed inhibitory effects not only on its spontaneous contraction, but also on acetylcholine (Ach, 0.1 mM)- and KCl (60 mM)-induced contractions. Furthermore, the ethanol extract (0.4-0.6 mg/ml) shifted the CaCl2 dose-effect curves to the right in a non-competitive manner and significantly reduced the acetylcholine-induced contraction of isolated ileum in Ca2+-free solution like verapamil (0.1 mM), which suggest that the extract interferes with Ca2+ movement. These results support the traditional use of Gentianopsis paludosa in the treatment of diarrhoea. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
语种英语
原文出处查看原文
WOS记录号WOS:000237101300016
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/93693
专题中国科学院大连化学物理研究所
通讯作者Wang HD(王焕弟)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Nat Prod & Glycoconjugate Res Grp 1805, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Microfluid Syst Biol, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Dalian, Peoples R China
推荐引用方式
GB/T 7714
Wang, HD,Tan, CY,Bai, XF,et al. Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):114-117.
APA Wang, HD,Tan, CY,Bai, XF,Du, YG,Lin, BC,&王焕弟.(2006).Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa.JOURNAL OF ETHNOPHARMACOLOGY,105(1-2),114-117.
MLA Wang, HD,et al."Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa".JOURNAL OF ETHNOPHARMACOLOGY 105.1-2(2006):114-117.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, HD]的文章
[Tan, CY]的文章
[Bai, XF]的文章
百度学术
百度学术中相似的文章
[Wang, HD]的文章
[Tan, CY]的文章
[Bai, XF]的文章
必应学术
必应学术中相似的文章
[Wang, HD]的文章
[Tan, CY]的文章
[Bai, XF]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。