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题名: Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa
作者: Wang, HD;  Tan, CY;  Bai, XF;  Du, YG;  Lin, BC
通讯作者: 王焕弟
关键词: Gentianopsis paludosa ;  anti-diarrhoeal ;  isolated ileum
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2006-04-21
DOI: 10.1016/j.jep.2005.10.002
卷: 105, 期:1-2, 页:114-117
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: The pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa were carried out. The 75% ethanol extract (100-400 mg/kg) of Gentianopsis paludosa inhibited castor oil-induced diarrhoea and also reduced gastrointestinal motility in the charcoal meal test in mice. In the rabbit-isolated ileum, the extract showed inhibitory effects not only on its spontaneous contraction, but also on acetylcholine (Ach, 0.1 mM)- and KCl (60 mM)-induced contractions. Furthermore, the ethanol extract (0.4-0.6 mg/ml) shifted the CaCl2 dose-effect curves to the right in a non-competitive manner and significantly reduced the acetylcholine-induced contraction of isolated ileum in Ca2+-free solution like verapamil (0.1 mM), which suggest that the extract interferes with Ca2+ movement. These results support the traditional use of Gentianopsis paludosa in the treatment of diarrhoea. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
关键词[WOS]: EXTRACT ;  ILEUM ;  RATS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000237101300016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/93693
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Nat Prod & Glycoconjugate Res Grp 1805, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Microfluid Syst Biol, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Sch, Dalian, Peoples R China

Recommended Citation:
Wang, HD,Tan, CY,Bai, XF,et al. Pharmacological studies of anti-diarrhoeal activity of Gentianopsis paludosa[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):114-117.
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