中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Investigations into the analysis and modeling of the cytochrome P450 cycle
作者: Wang, YH;  Li, Y;  Li, YH;  Ma, XH;  Yang, SL;  Yang, L
通讯作者: 杨凌
刊名: JOURNAL OF PHYSICAL CHEMISTRY B
发表日期: 2006-05-25
DOI: 10.1021/jp061119i
卷: 110, 期:20, 页:10139-10143
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
英文摘要: The main focus of our research is to explore the fundamental dynamics of the mechanism of the cytochrome P450 ( CYP450) cycle. For this purpose we propose a system- theoretical approach, a time- dependent metabolic control analysis ( tdMCA), to the analysis and quantitative modeling of the CYP450 catalytic pathway. This provides theoretical enlightenment for us to assess the transient response of the system to perturbations. In addition, the robustness of the cycle has also been observed, where perturbations elicit very weak responses and the system quickly recovers to the steady state ( in an average of 10(-5) s). The tdMCA also shows that the two electron transfers to the cycle have different impacts on the system, and the cycle is more sensitive to the first electron than to the second one. Knowing the dynamics of transient fluctuations, the robustness of the cycle, and the effects from the key interim steps, one has a deeper understanding of the catalytic mechanism of cytochrome P450.
关键词[WOS]: METABOLIC-CONTROL ANALYSIS ;  ELECTRON-TRANSFER ;  CONFORMATIONAL-CHANGE ;  STEADY-STATE ;  1A2 ;  OXIDATIONS ;  SYSTEMS ;  STEPS ;  P450 ;  PURIFICATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000237626400059
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/93813
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Sch Chem Engn, Dalian 116012, Peoples R China

Recommended Citation:
Wang, YH,Li, Y,Li, YH,et al. Investigations into the analysis and modeling of the cytochrome P450 cycle[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2006,110(20):10139-10143.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wang, YH]'s Articles
 [Li, Y]'s Articles
 [Li, YH]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wang, YH]‘s Articles
 [Li, Y]‘s Articles
 [Li, YH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace