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题名: Preparation and function of oligopeptide-enriched hydrolysate from globin by pepsin
作者: Yu, Y;  Hu, R;  Bai, X;  Du, Y;  Lin, B
通讯作者: 杜昱光
关键词: globin ;  angiotensin-I-converting enzyme ;  alpha-glucosidase ;  inhibitory activity
刊名: PROCESS BIOCHEMISTRY
发表日期: 2006-07-01
DOI: 10.1016/j.procbio.2006.03.001
卷: 41, 期:7, 页:1589-1593
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Technology
类目[WOS]: Biochemistry & Molecular Biology ;  Biotechnology & Applied Microbiology ;  Engineering, Chemical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biotechnology & Applied Microbiology ;  Engineering
英文摘要: Animal blood is potentially an untapped source of drugs and value-added food production. More than 400 million pigs are slaughtered each year but porcine blood is usually discarded in China. In this paper, globin derived from porcine hemoglobin was digested by pepsin, then the hydrolysate was separated on Sephadex LH-20 gel filtration column and five major fractions (I, II, III, IV and V) were obtained. Biological functions of the hydrolysate and five fractions were assayed. The hydrolysate and fractions IV and V had good angiotensin-l-converting enzyme inhibitory activity, with IC50 values of 1.19, 0.67, 0.10 mg/ml, respectively. Fractions I, II, III, IV showed no significant alpha-glucosidase inhibitory activity, but fraction V showed appreciably stronger activity than acarbose at the same concentration. Thus, the study has shown that porcine blood can be utilized to generate high value-added products, ACE inhibitory peptides and a-glucosidase inhibitory peptides. (c) 2006 Elsevier Ltd. All rights reserved.
关键词[WOS]: ENZYME-INHIBITORY PEPTIDES ;  ANGIOTENSIN-CONVERTING ENZYME ;  SPONTANEOUSLY HYPERTENSIVE RATS ;  ALPHA-GLUCOSIDASE INHIBITORS ;  SOY-PROTEIN ;  IDENTIFICATION ;  FOOD
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000238237500017
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/93815
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Bingjing 100049, Peoples R China

Recommended Citation:
Yu, Y,Hu, R,Bai, X,et al. Preparation and function of oligopeptide-enriched hydrolysate from globin by pepsin[J]. PROCESS BIOCHEMISTRY,2006,41(7):1589-1593.
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