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题名: Biological fingerprinting analysis by liquid chromatography/mass spectrometry for evaluation of DNA structural selectivity of multiple compounds in natural products
作者: Su, Xingye;  Kong, Liang;  Li, Xin;  Chen, Xueguo;  Guo, Ming;  Zou, Hanfa
通讯作者: 邹汉法
刊名: JOURNAL OF COMBINATORIAL CHEMISTRY
发表日期: 2006-07-10
DOI: 10.1021/cc060039l
卷: 8, 期:4, 页:544-550
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Applied ;  Chemistry, Medicinal ;  Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: A method by combination of centrifugal ultrafiltration (CUF) sampling with liquid chromatography-mass spectrometry (LC-MS) analysis was established to evaluate the DNA structure and sequence selectivity of the multiple compounds in a small molecule library. The developed method was applied to analyze the extracts of natural products Coptis chinensis Franch and Rheum palmatum (L.). From the obtained biological fingerprinting chromatograms, 7 compounds in C. chinensis Franch and 11 in R. palmatum ( L.) were screened out as DNA binding agents. Most of these compounds were identified by standards and LC-MS analysis after the sample pretreatment with the DNA immobilized cartridge. DNA structural binding preference of the multiple active compounds in these two extracts was then evaluated simultaneously without purification.
关键词[WOS]: BINDING LIGANDS ;  RHEUM-PALMATUM ;  DRUG DESIGN ;  ANTHRAQUINONE ;  RHUBARB ;  MICRODIALYSIS ;  MITOXANTRONE ;  DIALYSIS ;  PROTEIN ;  PHASE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000238848900015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/93877
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Dept Chem & Chem Technol, Dalian 116622, Peoples R China

Recommended Citation:
Su, Xingye,Kong, Liang,Li, Xin,et al. Biological fingerprinting analysis by liquid chromatography/mass spectrometry for evaluation of DNA structural selectivity of multiple compounds in natural products[J]. JOURNAL OF COMBINATORIAL CHEMISTRY,2006,8(4):544-550.
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