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题名: A preliminary study on fabrication of nanoscale fibrous chitosan membranes in situ by biospecific degradation
作者: Ren, Dongwen;  Yi, Hongfu;  Zhang, Huaan;  Xie, Weiyang;  Wang, Wei;  Ma, Xiaojun
通讯作者: 马小军
关键词: chitosan ;  biospecific degradation ;  nanofibers ;  membrane ;  tissue engineering ;  drug delivery
刊名: JOURNAL OF MEMBRANE SCIENCE
发表日期: 2006-09-01
DOI: 10.1016/j.memsci.2006.01.011
卷: 280, 期:1-2, 页:99-107
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Technology ;  Physical Sciences
类目[WOS]: Engineering, Chemical ;  Polymer Science
研究领域[WOS]: Engineering ;  Polymer Science
英文摘要: A new approach for in situ fabrication of nanoscale fibrous chitosan membrane by biospecific degradation under physiological situation was studied. The chitosan binary blend membranes were fabricated by solvent casting of chitosan solution containing highly deacetylated chitosan (HDC) and moderately deacetylated chitosan (MDC) with different ratio. The biodegradation process was performed in PBS (pH 7.4) containing lysozyme at the temperature of 37 degrees C. Experimental results from weight loss, reducing sugar in surrounding media, FT-IR, X-ray diffraction, gel permeation chromatography (GPC) and SEM throughout the study showed that the biospecific degradation by lysozyme had removed MDC component selectively. When the ratio of MDC in the binary blend membranes amounted to 0.5, nanoscale domains of HDC and MDC were obtained, and thus a nanoscale fibrous structure was fabricated after biospecific degradation of MDC. This nanofibrous structure and the biospecific degradation of chitosan membranes can have potential advantages and interesting implications in tissue engineering and drug delivery. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: N-ACETYLATED CHITOSANS ;  POLYMER NANOFIBERS ;  LYSOZYME ;  PROTEIN ;  CHROMATOGRAPHY ;  COMPATIBILITY ;  MATRIX ;  CHITIN ;  FILMS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000239472900013
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/97127
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Ren, Dongwen,Yi, Hongfu,Zhang, Huaan,et al. A preliminary study on fabrication of nanoscale fibrous chitosan membranes in situ by biospecific degradation[J]. JOURNAL OF MEMBRANE SCIENCE,2006,280(1-2):99-107.
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