DICP OpenIR
Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography
Zhang, CN; Zhang, XZ; Zhang, Y; Xu, Q; Xiao, HB; Liang, XM; Liang XM(梁鑫淼); Liang XM(梁鑫淼)
KeywordPolygonum Cuspidatum Anthraquinone Estrogenic Activity Emodin
Source PublicationJOURNAL OF ETHNOPHARMACOLOGY
2006-04-21
DOI10.1016/j.jep.2005.10.029
Volume105Issue:1-2Pages:223-228
Indexed BySCI
SubtypeArticle
Department18
Funding Project1804,1803
Contribution Rank1;1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS KeywordDIETARY PHYTOESTROGENS ; MENOPAUSAL SYMPTOMS ; IN-VITRO ; REPLACEMENT ; EXTRACTS ; THERAPY ; CANCER ; WOMEN
AbstractThe estrogenic activity of traditional Chinese herb-Polygonum cuspidation Sieb. et Zucc. was investigated by a recombinant yeast screening (YES) assay. Anthraquinones are the main components in the plant, of which emodin is the most abundant one. The ethyl acetate fraction of the ethanol extract of Polygonum cuspidatum was separated on a silica gel TLC plate and seven sub-fractions were collected. The results of bioassay demonstrated that Hzs1 and Hzs6 showed higher estrogenic activities than that of others and the potency of these two compounds were approximately 10(-4) g/L and 10(-3) g/L, respectively. HPLC analysis was performed to determine the activities and the active components. Combining the results of HPLC analysis and estrogenic activity test by YES led to the conclusion that an unknown bioactive compound might exist in the extraction of Polygonum cuspidatum. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Language英语
URL查看原文
WOS IDWOS:000237101300031
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/97427
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiang XM(梁鑫淼); Liang XM(梁鑫淼)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Zhang, CN,Zhang, XZ,Zhang, Y,et al. Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):223-228.
APA Zhang, CN.,Zhang, XZ.,Zhang, Y.,Xu, Q.,Xiao, HB.,...&梁鑫淼.(2006).Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography.JOURNAL OF ETHNOPHARMACOLOGY,105(1-2),223-228.
MLA Zhang, CN,et al."Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography".JOURNAL OF ETHNOPHARMACOLOGY 105.1-2(2006):223-228.
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