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题名: Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography
作者: Zhang, CN;  Zhang, XZ;  Zhang, Y;  Xu, Q;  Xiao, HB;  Liang, XM
通讯作者: 梁鑫淼
关键词: Polygonum cuspidatum ;  anthraquinone ;  estrogenic activity ;  emodin
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2006-04-21
DOI: 10.1016/j.jep.2005.10.029
卷: 105, 期:1-2, 页:223-228
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1804,1803
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: The estrogenic activity of traditional Chinese herb-Polygonum cuspidation Sieb. et Zucc. was investigated by a recombinant yeast screening (YES) assay. Anthraquinones are the main components in the plant, of which emodin is the most abundant one. The ethyl acetate fraction of the ethanol extract of Polygonum cuspidatum was separated on a silica gel TLC plate and seven sub-fractions were collected. The results of bioassay demonstrated that Hzs1 and Hzs6 showed higher estrogenic activities than that of others and the potency of these two compounds were approximately 10(-4) g/L and 10(-3) g/L, respectively. HPLC analysis was performed to determine the activities and the active components. Combining the results of HPLC analysis and estrogenic activity test by YES led to the conclusion that an unknown bioactive compound might exist in the extraction of Polygonum cuspidatum. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
关键词[WOS]: DIETARY PHYTOESTROGENS ;  MENOPAUSAL SYMPTOMS ;  IN-VITRO ;  REPLACEMENT ;  EXTRACTS ;  THERAPY ;  CANCER ;  WOMEN
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000237101300031
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/97427
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Zhang, CN,Zhang, XZ,Zhang, Y,et al. Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography[J]. JOURNAL OF ETHNOPHARMACOLOGY,2006,105(1-2):223-228.
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