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题名: Quantitative determination of oxidized carbon nanotube probes in yeast by capillary electrophoresis with laser-induced fluorescence detection
作者: Xiao, Hua;  Zou, Hanfa;  Pan, Chensong;  Jiang, Xiaogang;  Le, X. Chris;  Yang, Ling
通讯作者: 邹汉法
关键词: capillary electrophoresis ;  laser-induced fluorescence detection ;  carbon nanotube probes ;  yeast ;  apparent permeability coefficient
刊名: ANALYTICA CHIMICA ACTA
发表日期: 2006-11-24
DOI: 10.1016/j.aca.2006.07.074
卷: 580, 期:2, 页:194-199
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Short oxidized multi-walled carbon nanotubes were functionalized with fluorescein isothiocyanate to form carbon nanotube probes (CNTP). The distribution of CNTP in yeast was quantitatively determined by capillary electrophoresis coupled with laser-induced fluorescence detection. The detection sensitivity for CNTP was greatly improved comparing with UV absorbance and Raman detection. The time- and temperature-dependent influx patterns of CNTP into yeast were obtained. The apparent permeability coefficient for influx of CNTP into yeast was calculated, which suggested that CNTP might permeate into yeast through endocytosis. This study implies that CNTP could be a fine drug transporter and might be wildly used in multidrug resistance research and microorganism detection. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: DRUG-DELIVERY ;  TRANSPORTERS ;  CANCER ;  CELLS ;  SEPARATIONS ;  FIELD ;  DNA
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000242304800011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/97439
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&A Ctr, Dalian 116023, Peoples R China
2.Univ Alberta, Fac Med, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada
3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China

Recommended Citation:
Xiao, Hua,Zou, Hanfa,Pan, Chensong,et al. Quantitative determination of oxidized carbon nanotube probes in yeast by capillary electrophoresis with laser-induced fluorescence detection[J]. ANALYTICA CHIMICA ACTA,2006,580(2):194-199.
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