DICP OpenIR
Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts
Li, QR; Wang, M; Tan, L; Wang, C; Ma, J; Li, N; Li, YS; Xu, GW; Li, JS; Xu GW(许国旺); Xu GW(许国旺)
KeywordPolyunsaturated Fatty Acids Lipid Rafts Fatty Acid Composition Janus Kinase-signal Transducer And Activator Of Transcription Signaling Pathway
Source PublicationJOURNAL OF LIPID RESEARCH
2005-09-01
DOI10.1194/jlr.M500033-JLR200
Volume46Issue:9Pages:1904-1913
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank2;4
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemistry & Molecular Biology
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordPOLYUNSATURATED FATTY-ACIDS ; PROTEIN-TYROSINE KINASES ; DIETARY FISH-OIL ; RHEUMATOID-ARTHRITIS ; GPI-MICRODOMAINS ; RECEPTOR ; ACTIVATION ; PATHWAY ; STATS ; SUPPLEMENTATION
AbstractPolyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T-cell activation are not yet elucidated. Lipid rafts have been shown to play an important role in the compartmentalization and modulation of cell signaling. We investigated the role of DHA in modulating the lipid composition in lipid rafts and membrane subdomain distribution of interleukin-2 ( IL-2) receptor signaling molecules. We found that DHA altered lipid components of rafts and modified the IL-2-induced Janus kinase-signal transducer and activator of transcription (STAT) signaling pathway by partially displacing IL-2 receptors from lipid rafts. We fractionated plasma membrane subcellular compartments and discovered that certain amounts of STAT5a and STAT5b existed in detergent-resistant plasma membrane fractions of T-cells. After DHA treatment, STAT5a and STAT5b were not detected in lipid raft fractions and were located in detergent-soluble fractions. These data demonstrate for the first time that DHA alters the lipid composition of membrane microdomains and suppresses IL-2 receptor signaling in T- cells. Thus, our data provide evidence for a functional modification in lipid rafts by DHA treatment and explain PUFA- mediated immunosuppressive effects.
Language英语
URL查看原文
WOS IDWOS:000231244200012
Citation statistics
Cited Times:94[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/97481
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺); Xu GW(许国旺)
Affiliation1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
3.Chinese Acad Sci, Inst Chem Phys, Dalian 116011, Peoples R China
Recommended Citation
GB/T 7714
Li, QR,Wang, M,Tan, L,et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts[J]. JOURNAL OF LIPID RESEARCH,2005,46(9):1904-1913.
APA Li, QR.,Wang, M.,Tan, L.,Wang, C.,Ma, J.,...&许国旺.(2005).Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts.JOURNAL OF LIPID RESEARCH,46(9),1904-1913.
MLA Li, QR,et al."Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts".JOURNAL OF LIPID RESEARCH 46.9(2005):1904-1913.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, QR]'s Articles
[Wang, M]'s Articles
[Tan, L]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, QR]'s Articles
[Wang, M]'s Articles
[Tan, L]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, QR]'s Articles
[Wang, M]'s Articles
[Tan, L]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.