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Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts
Li, QR; Wang, M; Tan, L; Wang, C; Ma, J; Li, N; Li, YS; Xu, GW; Li, JS; Xu GW(许国旺); Xu GW(许国旺)
关键词Polyunsaturated Fatty Acids Lipid Rafts Fatty Acid Composition Janus Kinase-signal Transducer And Activator Of Transcription Signaling Pathway
刊名JOURNAL OF LIPID RESEARCH
2005-09-01
DOI10.1194/jlr.M500033-JLR200
46期:9页:1904-1913
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名2;4
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]POLYUNSATURATED FATTY-ACIDS ; PROTEIN-TYROSINE KINASES ; DIETARY FISH-OIL ; RHEUMATOID-ARTHRITIS ; GPI-MICRODOMAINS ; RECEPTOR ; ACTIVATION ; PATHWAY ; STATS ; SUPPLEMENTATION
英文摘要Polyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T-cell activation are not yet elucidated. Lipid rafts have been shown to play an important role in the compartmentalization and modulation of cell signaling. We investigated the role of DHA in modulating the lipid composition in lipid rafts and membrane subdomain distribution of interleukin-2 ( IL-2) receptor signaling molecules. We found that DHA altered lipid components of rafts and modified the IL-2-induced Janus kinase-signal transducer and activator of transcription (STAT) signaling pathway by partially displacing IL-2 receptors from lipid rafts. We fractionated plasma membrane subcellular compartments and discovered that certain amounts of STAT5a and STAT5b existed in detergent-resistant plasma membrane fractions of T-cells. After DHA treatment, STAT5a and STAT5b were not detected in lipid raft fractions and were located in detergent-soluble fractions. These data demonstrate for the first time that DHA alters the lipid composition of membrane microdomains and suppresses IL-2 receptor signaling in T- cells. Thus, our data provide evidence for a functional modification in lipid rafts by DHA treatment and explain PUFA- mediated immunosuppressive effects.
语种英语
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WOS记录号WOS:000231244200012
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文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/97481
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺); Xu GW(许国旺)
作者单位1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China
2.Chinese Acad Sci, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China
3.Chinese Acad Sci, Inst Chem Phys, Dalian 116011, Peoples R China
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Li, QR,Wang, M,Tan, L,et al. Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts[J]. JOURNAL OF LIPID RESEARCH,2005,46(9):1904-1913.
APA Li, QR.,Wang, M.,Tan, L.,Wang, C.,Ma, J.,...&许国旺.(2005).Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts.JOURNAL OF LIPID RESEARCH,46(9),1904-1913.
MLA Li, QR,et al."Docosahexaenoic acid changes lipid composition and interleukin-2 receptor signaling in membrane rafts".JOURNAL OF LIPID RESEARCH 46.9(2005):1904-1913.
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