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题名: Synthesis of silica-based benzeneboronic acid affinity materials and application as pre-column in coupled-column high-performance liquid chromatography
作者: Li, Fanglou;  Zhao, Xinjie;  Wang, Wenzhao;  Xu, Guowang
通讯作者: 许国旺
关键词: benzeneboronic acid-substituted silica ;  coupled-column ;  high-performance affinity chromatography ;  high-performance liquid chromatography ;  direct analysis ;  urinary nucleosides
刊名: ANALYTICA CHIMICA ACTA
发表日期: 2006-11-24
DOI: 10.1016/j.aca.2006.07.058
卷: 580, 期:2, 页:181-187
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: Three silica-based benzeneboronic acid affinity materials were synthesized by using an in-aminobenzeneboronic acid as the ligand and using three different spacer arms. Under high-pressure, three affinity pre-columns were packed with these materials and the retention of every affinity pre-column with 11 urinary nucleosides was studied. With different spacer arms of boronic acid-substituted silica materials, the absorption to vicinal alcohols (cis-diols) and stability under acidic elution conditions are of great difference. Coupled-column liquid chromatographic methods for the direct analysis of urinary nucleosides were respectively established. As a result, two of three affinity pre-columns showed good chromatographic property in the on-line analysis of urinary nucleosides. The coupled-column system including pre-column I is the best with excellent linearity (R-2 > 0.995), good recoveries (85.6-96.9%) and reproducibility (R.S.D.: 1.01-4.02%). The pre-column 1 could at least endure 150 repetitive injections of a 100 mu L urinary sample. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: BIOLOGICAL-FLUIDS ;  NUCLEOSIDES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000242304800009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/97599
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Li, Fanglou,Zhao, Xinjie,Wang, Wenzhao,et al. Synthesis of silica-based benzeneboronic acid affinity materials and application as pre-column in coupled-column high-performance liquid chromatography[J]. ANALYTICA CHIMICA ACTA,2006,580(2):181-187.
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