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题名: Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy
作者: Jia, Lewen;  Wang, Chang;  Kong, Hongwei;  Cai, Zongwei;  Xu, Guowang
通讯作者: 许国旺
关键词: metabonomics ;  phospholipid ;  IgA nephropathy ;  intercellular adhesion molecule-1 ;  high performance liquid chromatography ;  mass spectrometry
刊名: METABOLOMICS
发表日期: 2006-06-01
DOI: 10.1007/s11306-006-0025-3
卷: 2, 期:2, 页:95-104
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: IgA nephropathy is the most common form of glomerulonephritis (GN) and it Could progress to end-stage renal failure within 10 years. Participating in biological processes in various pathways, phospholipids as a class of important Constituents in the biomembranes have been paid increasing attention in many fields. However, phospholipids metabolism in glomerular disease was not clear, especially in IgA nephropathy. In this paper, the plasma phospholipid metabolic profile in mouse IgA nephropathy was investigated to discover the potential biomarkers on the progression of this disease by using high performance liquid chromatography/mass spectrometry (HPLC/MS) and the principal components analysis (PCA) as well as partial least squares-discriminant analysis (PLS-DA). The experimental mouse models of IgA nephropathy were established by oral immune and BSA injection. It was found that expression of intercellular adhesion molecule-1 (ICAM-1) in the glomeruli had a significant correlation with proteinuria in mouse IgA nephropathy. The association between plasma phospholipids and expression of ICAM-1 in the glomeruli of IgA nephropathy suggested C18:0/CI8:0 PS (phosphatidylserine), C18:0/C22:5 PS (phosphatidylserine) and C18:0/ C20:4 PI (phosphatidylinositol) were possible biomarkers of IgA nephropathy. The results show that the plasma phospholipid metabolic profiles from HPLC/MS combining with PCA and PLS-DA can be used not only to differentiate the IgA nephropathy from the controls, but also to discover and identify the potential biomarkers.
关键词[WOS]: TANDEM MASS-SPECTROMETRY ;  LIQUID-CHROMATOGRAPHY ;  RAT URINE ;  METABONOMICS ;  IDENTIFICATION ;  GENE ;  RECOGNITION ;  EXPRESSION ;  DIAGNOSIS ;  CANCER
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000245261200005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/97611
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China
3.Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China

Recommended Citation:
Jia, Lewen,Wang, Chang,Kong, Hongwei,et al. Plasma phospholipid metabolic profiling and biomarkers of mouse IgA nephropathy[J]. METABOLOMICS,2006,2(2):95-104.
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