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High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis B
Yang, J; Zhao, XJ; Liu, XL; Wang, C; Gao, P; Wang, JS; Li, LJ; Gu, JR; Yang, SL; Xu, GW; Xu GW(许国旺); Xu GW(许国旺)
关键词Metabonomics Hepatitis Lc Ms Pls-da Serum Biomarker
刊名JOURNAL OF PROTEOME RESEARCH
2006-03-01
DOI10.1021/pr050364w
5期:3页:554-561
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemical Research Methods
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]MULTIVARIATE STATISTICAL-ANALYSIS ; HIGH-RESOLUTION NMR ; H-1-NMR SPECTROSCOPY ; PATTERN-RECOGNITION ; IDENTIFYING DIFFERENCES ; METABOLOMIC ANALYSES ; HIGH-THROUGHPUT ; OA-TOF ; SAMPLES ; URINE
英文摘要Metabonomics methods have been successfully applied to the drug discovery, toxicology, phytochemistry, and clinical fields. Here, we report a self-developed metabonomics platform which is based on high performance liquid chromatog raphy- mass spectrometry (HPLC-MS) technique and applied to the investigation of acute deterioration of liver function in chronic hepatitis B to find the potential biomarkers. Sera from 50 healthy persons and 37 patients with acute deterioration of liver function in chronic hepatitis B were analyzed by HPLC-MS after removal of proteins. After de-noise, peak detection A, and peak alignment, the data of metabolites were fed to partial least squares discriminant analysis (PLS-DA) to find the potential biomarkers. According to the corresponding tandem mass results, several potential biomarkers were identified: Lysophosphaticlyl Choline (LPC) C18:0, LPC C16:0, LPC C18:1, LPC C18:2, and glycochenodeoxycholic acid (GCDCA) (or its isomer glycocleoxycholic acid (GDCA)). On the basis of the relevant literature and pathway databases, the biological significance of the present study is discussed.
语种英语
原文出处查看原文
WOS记录号WOS:000235897000011
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/97617
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺); Xu GW(许国旺)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou 310027, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Canc Inst, Natl Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Res Ctr Biotechnol, Shanghai, Peoples R China
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GB/T 7714
Yang, J,Zhao, XJ,Liu, XL,et al. High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis B[J]. JOURNAL OF PROTEOME RESEARCH,2006,5(3):554-561.
APA Yang, J.,Zhao, XJ.,Liu, XL.,Wang, C.,Gao, P.,...&许国旺.(2006).High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis B.JOURNAL OF PROTEOME RESEARCH,5(3),554-561.
MLA Yang, J,et al."High performance liquid chromatography-mass spectrometry for metabonomics: Potential biomarkers for acute deterioration of liver function in chronic hepatitis B".JOURNAL OF PROTEOME RESEARCH 5.3(2006):554-561.
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