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A new terbium(III) chelate as an efficient singlet oxygen fluorescence probe
Tan, MQ; Song, B; Wang, GL; Yuan, JL; Yuan JL(袁景利); Yuan JL(袁景利)
关键词Terbium Fluorescence Probe Singlet Oxygen Time-resolved Fluorescence Detection Free Radicals
刊名FREE RADICAL BIOLOGY AND MEDICINE
2006-05-01
ISSN0891-5849
DOI10.1016/j.freeradbiomed.2005.12.030
40期:9页:1644-1653
收录类别SCI
文章类型Article
部门归属1
项目归属101
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]PEROXIDASE-CATALYZED OXIDATION ; HYDROGEN-PEROXIDE ; MOLECULAR-OXYGEN ; BIOANALYTICAL ASSAYS ; PHOTODYNAMIC THERAPY ; RATIONAL DESIGN ; MURINE TUMOR ; GENERATION ; SENSITIZER ; IDENTIFICATION
英文摘要A terbium(III) chelate fluorescence probe for detection of singlet oxygen (102) in aqueous media, NNN',N-[2,6-bis(3'-aminomethyl-l'pyrazolyi)-4-(9"-anthryl)pyridine] tetrakis (acetate)-Tb3+ (PATA-Tb3+), was designed and synthesized. The new chelate is highly water soluble, is almost nonfluorescent, and can specifically react with O-1(2) to yield a strongly fluorescent chelate, the endoperoxide of PATA-Tb3+, accompanied by a remarkable increase in the fluorescence quantum yield from 0.46 to 10.5%. The long fluorescence lifetime of the endoperoxide (2.76 ms) allows the probe to be used favorably for time-resolved fluorescence detection Of O-1(2). The studies of fluorescence property and reaction specificity indicate that the new probe is highly sensitive and selective for O-1(2). The probe was used for quantitative detection Of O-1(2) generated from a MoO42--H2O2 system to give a detection limit of 10.8 nM. In addition, the good applicability of the probe was demonstrated by the real-time monitoring of the kinetic process of O-1(2) generation in a horseradish peroxidase-catalyzed oxidation system of indole-3-acetic acid in a weakly acidic buffer. (c) 2006 Elsevier Inc. All rights reserved.
语种英语
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WOS记录号WOS:000237433900016
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/97921
专题中国科学院大连化学物理研究所
通讯作者Yuan JL(袁景利); Yuan JL(袁景利)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Grad Sch, Dept Analyt Chem, Dalian 116023, Peoples R China
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GB/T 7714
Tan, MQ,Song, B,Wang, GL,et al. A new terbium(III) chelate as an efficient singlet oxygen fluorescence probe[J]. FREE RADICAL BIOLOGY AND MEDICINE,2006,40(9):1644-1653.
APA Tan, MQ,Song, B,Wang, GL,Yuan, JL,袁景利,&袁景利.(2006).A new terbium(III) chelate as an efficient singlet oxygen fluorescence probe.FREE RADICAL BIOLOGY AND MEDICINE,40(9),1644-1653.
MLA Tan, MQ,et al."A new terbium(III) chelate as an efficient singlet oxygen fluorescence probe".FREE RADICAL BIOLOGY AND MEDICINE 40.9(2006):1644-1653.
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