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题名: Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity
作者: Liang, Aiye;  Zhou, Xiaomian;  Wang, Qiuyan;  Liu, Xin;  Liu, Xiaojun;  Du, Yuguang;  Wang, Keyi;  Lin, Bingcheng
通讯作者: 林炳承
关键词: carrageenan ;  granulocyte colony-stimulating factor ;  interaction ;  capillary zone electrophoresis ;  leukemia cells
刊名: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
发表日期: 2006-10-20
DOI: 10.1016/j.jchromb.2006.05.029
卷: 843, 期:1, 页:114-119
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The effects of carrageenans' structural features on its interaction with granulocyte colony-stimulating factor (G-CSF) and on the growth and differentiation of a G-CSF dependent leukemia cell line (NFS-60) were studied. X, L, and K carrageenans, with decreasing contents of sulfation, bound to G-CSF with binding constants of (6.2 +/- 0.6) x 10(5) M-1, (7.4 +/- 0.5) x 10(5) M-1 and (6.0 +/- 0.4) x 10(5) M-1, and with 27.7 +/- 0.2, 17.4 +/- 0.1 and 8.4 +/- 0.1 binding sites, respectively. However, K carrageenan oligosaccharide had no affinity for G-CSF. The three carrageenans significantly inhibited G-CSF-induced growth of NFS-60 cells. The high sulfate content X carrageenan could also induce the maturation of the cells, but relatively low sulfate content L and K carrageenans could not. The results suggested that G-CSF-carrageenan bindings were dependent on carrageenans' sulfate contents and chain lengths, which could also affect the growth and differentiation of NFS-60 cells. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: COLONY-STIMULATING FACTOR ;  SULFATED POLYSACCHARIDES ;  ANTIVIRAL ACTIVITY ;  CELL ;  VIRUS ;  PROTEOGLYCANS ;  LEUKEMIA ;  PROTEIN ;  NFS-60 ;  ACID
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000241472400016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98073
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Acad Life SCi, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China

Recommended Citation:
Liang, Aiye,Zhou, Xiaomian,Wang, Qiuyan,et al. Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2006,843(1):114-119.
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