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Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity
Liang, Aiye; Zhou, Xiaomian; Wang, Qiuyan; Liu, Xin; Liu, Xiaojun; Du, Yuguang; Wang, Keyi; Lin, Bingcheng; Lin BC(林炳承); Lin BC(林炳承)
关键词Carrageenan Granulocyte Colony-stimulating Factor Interaction Capillary Zone Electrophoresis Leukemia Cells
刊名JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2006-10-20
DOI10.1016/j.jchromb.2006.05.029
843期:1页:114-119
收录类别SCI
文章类型Article
部门归属18
项目归属1807
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]COLONY-STIMULATING FACTOR ; SULFATED POLYSACCHARIDES ; ANTIVIRAL ACTIVITY ; CELL ; VIRUS ; PROTEOGLYCANS ; LEUKEMIA ; PROTEIN ; NFS-60 ; ACID
英文摘要The effects of carrageenans' structural features on its interaction with granulocyte colony-stimulating factor (G-CSF) and on the growth and differentiation of a G-CSF dependent leukemia cell line (NFS-60) were studied. X, L, and K carrageenans, with decreasing contents of sulfation, bound to G-CSF with binding constants of (6.2 +/- 0.6) x 10(5) M-1, (7.4 +/- 0.5) x 10(5) M-1 and (6.0 +/- 0.4) x 10(5) M-1, and with 27.7 +/- 0.2, 17.4 +/- 0.1 and 8.4 +/- 0.1 binding sites, respectively. However, K carrageenan oligosaccharide had no affinity for G-CSF. The three carrageenans significantly inhibited G-CSF-induced growth of NFS-60 cells. The high sulfate content X carrageenan could also induce the maturation of the cells, but relatively low sulfate content L and K carrageenans could not. The results suggested that G-CSF-carrageenan bindings were dependent on carrageenans' sulfate contents and chain lengths, which could also affect the growth and differentiation of NFS-60 cells. (c) 2006 Elsevier B.V. All rights reserved.
语种英语
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WOS记录号WOS:000241472400016
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98073
专题中国科学院大连化学物理研究所
通讯作者Lin BC(林炳承); Lin BC(林炳承)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Acad Life SCi, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China
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GB/T 7714
Liang, Aiye,Zhou, Xiaomian,Wang, Qiuyan,et al. Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2006,843(1):114-119.
APA Liang, Aiye.,Zhou, Xiaomian.,Wang, Qiuyan.,Liu, Xin.,Liu, Xiaojun.,...&林炳承.(2006).Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,843(1),114-119.
MLA Liang, Aiye,et al."Structural features in carrageenan that interact with a heparin-binding hematopoietic growth factor and modulate its biological activity".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 843.1(2006):114-119.
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