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题名: Prediction of the deleterious nsSNPs in ABCB transporters
作者: Li, Yanhong;  Wang, Yonghua;  Li, Yan;  Yang, Ling
通讯作者: 杨凌
关键词: prediction ;  deleterious nsSNPs ;  ABCB transporters ;  computational
刊名: FEBS LETTERS
发表日期: 2006-12-22
DOI: 10.1016/j.febslet.2006.11.047
卷: 580, 期:30, 页:6800-6806
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Cell Biology
英文摘要: The non-synonymous SNPs (nsSNPs) in coding regions, neutral or deleterious, could lead to the alteration of the function or structure of proteins. We have developed the computational models to analyze the deleterious nsSNPs in the transporters and predict ones in ABCB (ATP-binding cassette B) transporters of interest. The RPLS (ridge partial least square) and LDA (linear discriminant analysis) methods were applied to the problem, by training on a selection of datasets from a specified source, i.e., human transporters. The best combination of datasets and prediction attributes was ascertained. The prediction accuracy of the theoretical RPLS model for the training and testing sets is 84.8%, and 80.4%, respectively (LDA: 84.3'% and 80.4%), which indicates the models are reasonable and may be helpful for pharmacogenetics studies. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
关键词[WOS]: SINGLE-NUCLEOTIDE POLYMORPHISMS ;  ACCESSIBLE SURFACE-AREAS ;  SUPPORT VECTOR REGRESSION ;  PROTEIN-COUPLED RECEPTORS ;  SOLVENT ACCESSIBILITY ;  GENE POLYMORPHISMS ;  CHINESE PATIENTS ;  P-GLYCOPROTEIN ;  TAP2 GENE ;  MUTATIONS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000243266600008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98183
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmceut Resource Discovery, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Sch Chem Engn, Dalian 116012, Peoples R China

Recommended Citation:
Li, Yanhong,Wang, Yonghua,Li, Yan,et al. Prediction of the deleterious nsSNPs in ABCB transporters[J]. FEBS LETTERS,2006,580(30):6800-6806.
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