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Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus
Hao, Da-Cheng; Sun, Jie; Furnes, Bjarte; Schlenk, Daniel; Hou, Zhen-Fang; Zhang, Ya-Ping; Yang, Sheng-Li; Yang, Ling; Yang L(杨凌); Yang L(杨凌)
关键词Fmo3 Polymorphism Haplotype Frequency Linkage Evolution
刊名BIOCHEMICAL GENETICS
2006-08-01
DOI10.1007/s10528-006-9037-y
44期:7-8页:391-407
收录类别SCI
文章类型Article
部门归属18
项目归属1806
产权排名1;1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]FLAVIN-CONTAINING MONOOXYGENASE ; FAMILIAL ADENOMATOUS POLYPOSIS ; IN-VIVO ; N-OXIDATION ; CAFFEINE METABOLISM ; POPULATION ; FLAVIN-MONOOXYGENASE-3 ; IDENTIFICATION ; DISCOVERY ; VARIANTS
英文摘要We analyzed flavin-containing monooxygenase 3 (FMO3) polymorphisms, haplotype structure, and linkage disequilibrium (LD) in 256 Han Chinese and 50 African-American individuals to compare their haplotype frequencies and LD with other world populations. For the Han Chinese, genotyping of three haplotype tag single nucleotide polymorphisms (E158K, V257M, and E308G) was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism. For the African-Americans, genotyping of all coding exons was performed by modified PCR-single strand conformational polymorphism. Haplotype frequencies, LD, and evolutionary rates were inferred and estimated computationally. There were significant differences in haplotype frequency distribution and LD pattern among Han Chinese, African-Americans, and other world populations. Four major haplotypes of Han Chinese were EVE, KVE, EME, and EVG. Two major haplotypes of African-Americans were EVE and KVE. We found that sites 158 and 257 are in significant LD in both populations. This is the first report comparing FMO haplotypes and LD of Han Chinese with African-Americans. The data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes.
语种英语
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WOS记录号WOS:000242851100009
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98265
专题中国科学院大连化学物理研究所
通讯作者Yang L(杨凌); Yang L(杨凌)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Dalian Med Univ, Dept Emergency Med, Dalian, Peoples R China
3.Univ Calif Riverside, Environm Toxicol Program, Riverside, CA 92521 USA
4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming, Peoples R China
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GB/T 7714
Hao, Da-Cheng,Sun, Jie,Furnes, Bjarte,et al. Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus[J]. BIOCHEMICAL GENETICS,2006,44(7-8):391-407.
APA Hao, Da-Cheng.,Sun, Jie.,Furnes, Bjarte.,Schlenk, Daniel.,Hou, Zhen-Fang.,...&杨凌.(2006).Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus.BIOCHEMICAL GENETICS,44(7-8),391-407.
MLA Hao, Da-Cheng,et al."Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus".BIOCHEMICAL GENETICS 44.7-8(2006):391-407.
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