中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
题名: Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus
作者: Hao, Da-Cheng;  Sun, Jie;  Furnes, Bjarte;  Schlenk, Daniel;  Hou, Zhen-Fang;  Zhang, Ya-Ping;  Yang, Sheng-Li;  Yang, Ling
通讯作者: 杨凌
关键词: FMO3 ;  polymorphism ;  haplotype frequency ;  linkage ;  evolution
刊名: BIOCHEMICAL GENETICS
发表日期: 2006-08-01
DOI: 10.1007/s10528-006-9037-y
卷: 44, 期:7-8, 页:391-407
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1;1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemistry & Molecular Biology ;  Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ;  Genetics & Heredity
英文摘要: We analyzed flavin-containing monooxygenase 3 (FMO3) polymorphisms, haplotype structure, and linkage disequilibrium (LD) in 256 Han Chinese and 50 African-American individuals to compare their haplotype frequencies and LD with other world populations. For the Han Chinese, genotyping of three haplotype tag single nucleotide polymorphisms (E158K, V257M, and E308G) was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism. For the African-Americans, genotyping of all coding exons was performed by modified PCR-single strand conformational polymorphism. Haplotype frequencies, LD, and evolutionary rates were inferred and estimated computationally. There were significant differences in haplotype frequency distribution and LD pattern among Han Chinese, African-Americans, and other world populations. Four major haplotypes of Han Chinese were EVE, KVE, EME, and EVG. Two major haplotypes of African-Americans were EVE and KVE. We found that sites 158 and 257 are in significant LD in both populations. This is the first report comparing FMO haplotypes and LD of Han Chinese with African-Americans. The data presented here justify further pharmacogenetic studies for potentially optimizing recommended drug dosages and evaluating relationships with disease processes.
关键词[WOS]: FLAVIN-CONTAINING MONOOXYGENASE ;  FAMILIAL ADENOMATOUS POLYPOSIS ;  IN-VIVO ;  N-OXIDATION ;  CAFFEINE METABOLISM ;  POPULATION ;  FLAVIN-MONOOXYGENASE-3 ;  IDENTIFICATION ;  DISCOVERY ;  VARIANTS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000242851100009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98265
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian, Peoples R China
2.Dalian Med Univ, Dept Emergency Med, Dalian, Peoples R China
3.Univ Calif Riverside, Environm Toxicol Program, Riverside, CA 92521 USA
4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
5.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming, Peoples R China

Recommended Citation:
Hao, Da-Cheng,Sun, Jie,Furnes, Bjarte,et al. Haplotype frequency distribution and linkage disequilibrium analysis of single nucleotide polymorphisms at the human FMO3 gene locus[J]. BIOCHEMICAL GENETICS,2006,44(7-8):391-407.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Hao, Da-Cheng]'s Articles
 [Sun, Jie]'s Articles
 [Furnes, Bjarte]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Hao, Da-Cheng]‘s Articles
 [Sun, Jie]‘s Articles
 [Furnes, Bjarte]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace