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题名: Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza
作者: Guo, Yong-Xue;  Zhang, Dai-Jia;  Wang, Hui;  Xiu, Zhi-Long;  Wang, Long-Xing;  Xiao, Hong-Bin
通讯作者: Zhi-Long Xiu
关键词: lithospermic acid B ;  hydrolysis ;  kinetics ;  LC/MS
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2007-01-17
DOI: 10.1016/j.jpba.2006.07.046
卷: 43, 期:2, 页:435-439
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 2;5
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: The hydrolytic kinetics of lithospermic acid B (LAB) extracted from the roots of Salvia miltiorrhiza (Chinese herb: danshen) was investigated by using reversed-phase high-performance liquid chromatography (HPLC) with UV-vis detection. The influences of initial drug concentration, pH and temperature on hydrolysis of LAB were studied in aqueous solutions. The results showed that initial concentration of LAB has no effect on the degradation rate at pH 2.0. The hydrolysis followed pseudo-first-order kinetics at 90 degrees C. The log k(obs)-pH profile indicated that the optimal stability range was at pH 2.0-5.0. The rate constant of overall hydrolysis as a function of temperature under the given conditions obeyed the Arrhenius equation. Analysis of the acid-induced degraded solution of LAB by liquid chromatography-mass spectrometry (LC-MS) revealed at least four degradation products [M - H](-) ion at m/z 197, 137, 537 and 537, respectively. Three of these degradation products, i.e. danshensu (DSU), protocatechuic aldehyde (PRO), and lithospermic acid, were further identified by comparing the retention times with standard samples. According to the structure of LAB and its hydrolysis behavior in solution, the other product was proposed to be the isomer of lithospermic acid. (c) 2006 Elsevier B.V. All rights reserved.
关键词[WOS]: LIQUID-CHROMATOGRAPHY ;  MASS-SPECTROMETRY ;  MAGNESIUM ;  RATS ;  DEGRADATION ;  INHIBITION ;  RADIX
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000243802700006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98327
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Guo, Yong-Xue,Zhang, Dai-Jia,Wang, Hui,et al. Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,43(2):435-439.
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