DICP OpenIR
Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography
Ou, Junjie; Li, Xin; Feng, Shun; Dong, Jing; Dong, Xiaoli; Kong, Liang; Ye, Mingliang; Zou, Hanfa; Zou HF(邹汉法); Zou HF(邹汉法)
Source PublicationANALYTICAL CHEMISTRY
2007-01-15
ISSN0003-2700
DOI10.1021/ac061475x
Volume79Issue:2Pages:639-646
Indexed BySCI
SubtypeArticle
Department18
Funding Project1809
Contribution Rank1;1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordSTATIONARY PHASES ; ENANTIOMER SEPARATION ; ANALYTICAL-CHEMISTRY ; RECOGNITION ; SELECTIVITY ; PHARMACEUTICALS ; DIASTEREOMERS ; TECHNOLOGY ; COATINGS
AbstractA method for preparation of molecularly imprinted polymer (MIP) derivatized onto the surface of a monolithic silica capillary column was successfully developed. The vinyl groups were first introduced onto the silica monolith by immobilization of gamma-methacryloxypropyltrimethoxysilane. Then the MIP coating was copolymerized and anchored onto the surface of the silica monolith. Acetonitrile was selected as porogen (solvent). The other preparation conditions, such as monomer concentration, temperature, and time of polymerization, were systematically studied. The obtained MIP-derivatized silica monolith using L-tetrahydropalmatine (L-THP) and (5S,11S)-(-)-Troger's base (S-TB) as the imprinted template, respectively, was characterized in terms of the retention behavior of thiourea and toluene. Under the optimized CEC conditions, baseline enantioseparations of THP and TB were achieved in 4 min though the effective length of the columns was 8.5 cm. The result indicates that enough recognition sites were on the surface of silica monolith, resulting in strong recognition ability. Compared with a MIP organic monolith, the MIP-derivatized silica monolith exhibits better column efficiency and stability in CEC. Additionally, the comparison of these two kinds of monolithic columns was performed by capillary liquid chromatography. The separation on MIP-derivatized silica monolith was superior to that on the organic monolith.
Language英语
URL查看原文
WOS IDWOS:000243415800031
Citation statistics
Cited Times:126[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/98443
Collection中国科学院大连化学物理研究所
Corresponding AuthorZou HF(邹汉法); Zou HF(邹汉法)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China
Recommended Citation
GB/T 7714
Ou, Junjie,Li, Xin,Feng, Shun,et al. Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography[J]. ANALYTICAL CHEMISTRY,2007,79(2):639-646.
APA Ou, Junjie.,Li, Xin.,Feng, Shun.,Dong, Jing.,Dong, Xiaoli.,...&邹汉法.(2007).Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography.ANALYTICAL CHEMISTRY,79(2),639-646.
MLA Ou, Junjie,et al."Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography".ANALYTICAL CHEMISTRY 79.2(2007):639-646.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ou, Junjie]'s Articles
[Li, Xin]'s Articles
[Feng, Shun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ou, Junjie]'s Articles
[Li, Xin]'s Articles
[Feng, Shun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ou, Junjie]'s Articles
[Li, Xin]'s Articles
[Feng, Shun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.