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Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography
Ou, Junjie; Li, Xin; Feng, Shun; Dong, Jing; Dong, Xiaoli; Kong, Liang; Ye, Mingliang; Zou, Hanfa; Zou HF(邹汉法); Zou HF(邹汉法)
刊名ANALYTICAL CHEMISTRY
2007-01-15
ISSN0003-2700
DOI10.1021/ac061475x
79期:2页:639-646
收录类别SCI
文章类型Article
部门归属18
项目归属1809
产权排名1;1
WOS标题词Science & Technology ; Physical Sciences
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]STATIONARY PHASES ; ENANTIOMER SEPARATION ; ANALYTICAL-CHEMISTRY ; RECOGNITION ; SELECTIVITY ; PHARMACEUTICALS ; DIASTEREOMERS ; TECHNOLOGY ; COATINGS
英文摘要A method for preparation of molecularly imprinted polymer (MIP) derivatized onto the surface of a monolithic silica capillary column was successfully developed. The vinyl groups were first introduced onto the silica monolith by immobilization of gamma-methacryloxypropyltrimethoxysilane. Then the MIP coating was copolymerized and anchored onto the surface of the silica monolith. Acetonitrile was selected as porogen (solvent). The other preparation conditions, such as monomer concentration, temperature, and time of polymerization, were systematically studied. The obtained MIP-derivatized silica monolith using L-tetrahydropalmatine (L-THP) and (5S,11S)-(-)-Troger's base (S-TB) as the imprinted template, respectively, was characterized in terms of the retention behavior of thiourea and toluene. Under the optimized CEC conditions, baseline enantioseparations of THP and TB were achieved in 4 min though the effective length of the columns was 8.5 cm. The result indicates that enough recognition sites were on the surface of silica monolith, resulting in strong recognition ability. Compared with a MIP organic monolith, the MIP-derivatized silica monolith exhibits better column efficiency and stability in CEC. Additionally, the comparison of these two kinds of monolithic columns was performed by capillary liquid chromatography. The separation on MIP-derivatized silica monolith was superior to that on the organic monolith.
语种英语
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WOS记录号WOS:000243415800031
引用统计
被引频次:123[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/98443
专题中国科学院大连化学物理研究所
通讯作者Zou HF(邹汉法); Zou HF(邹汉法)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China
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GB/T 7714
Ou, Junjie,Li, Xin,Feng, Shun,et al. Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography[J]. ANALYTICAL CHEMISTRY,2007,79(2):639-646.
APA Ou, Junjie.,Li, Xin.,Feng, Shun.,Dong, Jing.,Dong, Xiaoli.,...&邹汉法.(2007).Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography.ANALYTICAL CHEMISTRY,79(2),639-646.
MLA Ou, Junjie,et al."Preparation and evaluation of a molecularly imprinted polymer derivatized silica monolithic column for capillary electrochromatography and capillary liquid chromatography".ANALYTICAL CHEMISTRY 79.2(2007):639-646.
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