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Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells
Zhang, Ying; Wang, Wei; Zhou, Jing; Yu, Weiting; Zhang, Xulang; Guo, Xin; Ma, Xiaojun; Ma XJ(马小军); Ma XJ(马小军)
KeywordMicroencapsulation Tumor Gene Therapy Endostatin Recombinant Cho Cells
Source PublicationANNALS OF BIOMEDICAL ENGINEERING
2007-04-01
ISSN0090-6964
DOI10.1007/s10439-007-9255-4
Volume35Issue:4Pages:605-614
Indexed BySCI
SubtypeArticle
Department18
Funding Project1802
Contribution Rank1;1
WOS HeadingsScience & Technology ; Technology
WOS SubjectEngineering, Biomedical
WOS Research AreaEngineering
WOS KeywordVIRUS-MEDIATED EXPRESSION ; DIABETES-MELLITUS ; ENDOTHELIAL-CELLS ; CARCINOMA GROWTH ; HUMAN ENDOSTATIN ; HEMOPHILIA-B ; CANCER ; MICE ; DELIVERY ; TECHNOLOGY
AbstractMicroencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from host's immune rejection, increase the chemical stability of therapeutic protein and circumvent the problems of toxicity, limited half-lives and variation in circulating levels. Endostatin, a potent and specific angiogenesis inhibitor, could suppress the growth of primary and metastatic lesions in multiple murine tumor models. In this paper, APA microcapsules with high strength kept intact over 35 days and recombinant CHO cells kept the rapid proliferation viability and the continuous endostatin-expression function. The study of tumor treatment showed that the implantation of microencapsulated recombinant CHO cells decreased the neovascularization of tumor tissue by 59.4% and inhibited the B16 melanoma growth by 77.4%. Twenty days after tumor cell injection, 80% of animals treated with microencapsulated CHO-endo cells were alive compared to only 50% of animals in either control or mock control groups. Therefore, continuous delivery of endostatin from microencapsulated recombinant cells represents a feasible approach to tumor therapy.
Language英语
URL查看原文
WOS IDWOS:000245078300009
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/98543
Collection中国科学院大连化学物理研究所
Corresponding AuthorMa XJ(马小军); Ma XJ(马小军)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ying,Wang, Wei,Zhou, Jing,et al. Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells[J]. ANNALS OF BIOMEDICAL ENGINEERING,2007,35(4):605-614.
APA Zhang, Ying.,Wang, Wei.,Zhou, Jing.,Yu, Weiting.,Zhang, Xulang.,...&马小军.(2007).Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells.ANNALS OF BIOMEDICAL ENGINEERING,35(4),605-614.
MLA Zhang, Ying,et al."Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells".ANNALS OF BIOMEDICAL ENGINEERING 35.4(2007):605-614.
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