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题名: Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells
作者: Zhang, Ying;  Wang, Wei;  Zhou, Jing;  Yu, Weiting;  Zhang, Xulang;  Guo, Xin;  Ma, Xiaojun
通讯作者: 马小军
关键词: microencapsulation ;  tumor gene therapy ;  endostatin ;  recombinant CHO cells
刊名: ANNALS OF BIOMEDICAL ENGINEERING
发表日期: 2007-04-01
DOI: 10.1007/s10439-007-9255-4
卷: 35, 期:4, 页:605-614
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 1;1
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical
研究领域[WOS]: Engineering
英文摘要: Microencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from host's immune rejection, increase the chemical stability of therapeutic protein and circumvent the problems of toxicity, limited half-lives and variation in circulating levels. Endostatin, a potent and specific angiogenesis inhibitor, could suppress the growth of primary and metastatic lesions in multiple murine tumor models. In this paper, APA microcapsules with high strength kept intact over 35 days and recombinant CHO cells kept the rapid proliferation viability and the continuous endostatin-expression function. The study of tumor treatment showed that the implantation of microencapsulated recombinant CHO cells decreased the neovascularization of tumor tissue by 59.4% and inhibited the B16 melanoma growth by 77.4%. Twenty days after tumor cell injection, 80% of animals treated with microencapsulated CHO-endo cells were alive compared to only 50% of animals in either control or mock control groups. Therefore, continuous delivery of endostatin from microencapsulated recombinant cells represents a feasible approach to tumor therapy.
关键词[WOS]: VIRUS-MEDIATED EXPRESSION ;  DIABETES-MELLITUS ;  ENDOTHELIAL-CELLS ;  CARCINOMA GROWTH ;  HUMAN ENDOSTATIN ;  HEMOPHILIA-B ;  CANCER ;  MICE ;  DELIVERY ;  TECHNOLOGY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000245078300009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98543
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Zhang, Ying,Wang, Wei,Zhou, Jing,et al. Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells[J]. ANNALS OF BIOMEDICAL ENGINEERING,2007,35(4):605-614.
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