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题名: Separation of basic and acidic compounds by capillary electrochromatography using monolithic silica capillary columns with zwitterionic stationary phase
作者: Hu, Jiwei;  Xie, Chuanhui;  Tian, Ruijun;  He, Zhike;  Zou, Hanfa
通讯作者: 何志柯 ;  邹汉法
关键词: basic compounds ;  capillary electrochromatography ;  electroosmotic flow ;  monolithic silica capillary column ;  zwitterionic stationary phase
刊名: JOURNAL OF SEPARATION SCIENCE
发表日期: 2007-04-01
DOI: 10.1002/jssc.200600173
卷: 30, 期:6, 页:891-899
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1809
产权排名: 2;1
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
英文摘要: A novel monolithic silica column with zwitterionic stationary phase was prepared by in-situ covalent attachment of phenylalanine to a 3-glycidoxypropyltriethoxysilane-modified silica monolith. Due to the zwitterionic nature of the resulting stationary phase, the density and sign of the net surface charge, and accordingly the direction and magnitude of electroosmotic flow in this column during capillary electrochromatography could be manipulated by adjusting the pH values of the mobile phase. CEC separations of various acidic and basic compounds were performed on the prepared column in anodic and weakly cathodic EOF modes, respectively. The peak tailing of basic compounds in CEC on a silica column could be alleviated at optimized buffer compositions. Besides the electrophoretic mechanism and weak hydrophobic interaction, weak cation- and anion-exchange interactions are also involved in the separations of acids and bases, respectively, on the zwitterionic column.
关键词[WOS]: REVERSED-PHASE ;  CHROMATOGRAPHIC CHARACTERIZATION ;  LIQUID-CHROMATOGRAPHY ;  ELECTROOSMOTIC FLOW ;  OCTADECYL MOIETIES ;  POLYMER MONOLITHS ;  ION-EXCHANGERS ;  PEPTIDES ;  PROTEINS ;  MEDIA
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000246348000014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/98547
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&D Ctr, Dalian, Peoples R China

Recommended Citation:
Hu, Jiwei,Xie, Chuanhui,Tian, Ruijun,et al. Separation of basic and acidic compounds by capillary electrochromatography using monolithic silica capillary columns with zwitterionic stationary phase[J]. JOURNAL OF SEPARATION SCIENCE,2007,30(6):891-899.
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